Results 21 to 30 of about 156,415 (241)

Longitudinal changes in physical self-perceptions and associations with physical activity during adolescence

open access: yes, 2011
The purpose of this study was to examine adolescents' physical self-perceptions and their associations with physical activity using a longitudinal perspective.
Inchley, Jo   +4 more
core   +1 more source

Body Culture within the EU's Competence System

open access: yes, 2011
Proficiency and habits in body culture cannot be disregarded when drawing up integrated cultural competences that meet the challenges of the 21st century.
Soos, Istvan   +10 more
core   +1 more source

Youth Motor Competence Promotion Model: A Quantitative Investigation into Modifiable Factors [PDF]

open access: yes, 2020
Objectives: This study aimed to quantify the relationships between enabling, predisposing and reinforcing ecological factors on motor competence and investigate potential sex, weight status, and school level differences.
Tyler, Richard   +14 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

A longitudinal examination of the influence of maturation on physical self-perceptions and the relationship with physical activity in early adolescent girls

open access: yes, 2009
This longitudinal study investigated the influence of maturation on physical self-perceptions and the relationship with physical activity in early adolescent girls (N = 150; mean age = 12.79 0.31).
Niven, Ailsa   +11 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Enhancing Motor Competence and Physical Activity in Kindergarten

open access: yesJournal of Physical Activity and Health, 2019
This study aimed at evaluating the effect of the "Walk," an 8-month physical activity (PA) program led by classroom and physical education teachers, on the motor competence (MC) and PA of 5- to 6-year-old children.A total of 143 children (mean age = 61.51 [1.85] mo) participated in the study and were randomly assigned to the experimental and control ...
Aivazidis, D.   +4 more
openaire   +3 more sources

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