Results 41 to 50 of about 104,124 (265)

Neighborhood Physical Conditions and Health

American Journal of Public Health, 2003
Objectives. We explored the relationship between boarded-up housing and rates of gonorrhea and premature mortality. Methods. In this ecological study of 107 US cities, we developed several models predicting rates of gonorrhea and premature death before age 65 from all causes and from specific causes.
Cohen, Deborah A., Mason, Karen, Bedimo, Ariane, Scribner, Richard, Basolo, Victoria, Farley, Thomas A.   +5 more
openaire   +4 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effect of Power Output and Pedaling Cadence on Plantar Pressures in Professional Cyclists with Overuse Injuries

Sports
Background: Plantar pressure analysis provides insight into load distribution at the foot–pedal interface during cycling; however, its modulation by pedaling power, cadence, and overuse injury status remains poorly understood by professional cyclists. It
Dídac Navarro-Martínez, Javier Zahonero, Pablo Vera, José Martí-Martí, Florentino Huertas, Carlos Barrios   +5 more
doaj   +1 more source

Subjective assessment and biochemical evaluation of traction therapy in women with chronic low back pain: does body mass index matter? A clinical study

BMC Musculoskeletal Disorders, 2023
Background Apart from the positive effect of lumbar traction on structural changes within the spine in patients with low back pain, it is likely that therapeutic effects are correlated with pain biomarkers in the blood.
Marzena Ratajczak, Michał Wendt, Ewa Śliwicka, Damian Skrypnik, Jacek Zieliński, Krzysztof Kusy, Piotr Krutki, Małgorzata Waszak   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Effects of variable resistance training with different load ratios on lower-limb strength and power in male college students

Journal of Exercise Science & Fitness
Objective: The optimum relationship combination of variable to constant resistance within variable resistance training (VRT) for enhancing lower-limb strength and power remains unclear.
Changbo Pan, Wei Li, Yuying Su, Yu Shi
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

A 24-week multi-component exercise program improves cognition and body composition in older adults with mild cognitive impairment: a randomized controlled trial

Frontiers in Aging Neuroscience
BackgroundThis study investigated whether a 24-week, community-based multicomponent exercise intervention (MCEI) can improve body composition and cognitive function in older adults with mild cognitive impairment (MCI).MethodsIn this single-center ...
Danming Xu, Xiaochu Wu, Junming Dai, Qing Li, Zhi Wang, Yimin Huang, Yu Zhang, Junjie Cao, Bingxue Li, Yirong Dong, Yanhao Tu   +10 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source