Results 61 to 70 of about 6,242,189 (313)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Postural control in top-level Para Karate athletes with visual and intellectual impairment: an observational study

BMC Sports Science, Medicine and Rehabilitation
Background Although the World Karate Federation (WKF) lacks a standardized test battery, Para Karate classification follows International Paralympic Committee (IPC) principles, with balance recognized as a key physical ability affecting kata performance.
Henrieta Horníková, Radovan Hadža, Michal Hrubý, Dušana Augustovičová   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Effects of physical activity distribution patterns on basketball skill acquisition and physical exercise self-efficacy among Chinese male university students: a randomised controlled trial [PDF]

PeerJ
Background As an open-skills sport, basketball not only enhances university students’ physical fitness and specialised techniques but also influences their technical learning efficiency and exercise self-efficacy through patterns of physical activity ...
Zhuoxiao Liu, Chengyu Zhou, Zhuo Zeng, Huaibo Yang   +3 more
doaj   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Spectator attendance without spectators: stakeholder insights from a national athletics championships

Frontiers in Sports and Active Living
IntroductionSpectator attendance at the national athletics championships in Slovakia has been low for a long time, despite free admission. Not even the elevated performance of Slovak athletes in certain disciplines and the growing media interest in ...
Monika Písečná, Iveta Cihová
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The Influence of Sleep and Autonomic Recovery on Performance in World-Class Swimmers at Major Competitions: The Qualifying Trials, World Championships, and Olympic Games

Sports
Sleep deprivation is one of the main risk factors for impaired performance in elite athletes, but the changes in sleep and autonomic regulation in response to competitions of varying levels within the same Olympic year remain unknown. In this prospective,
Lidia Barragán, Carmen Crespo, Sergio J. Ibáñez, Rafael Timón, Guillermo Olcina   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Acute Postexercise Change in Circulating Irisin Is Related to More Favorable Lipid Profile in Pregnant Women Attending a Structured Exercise Program and to Less Favorable Lipid Profile in Controls: An Experimental Study with Two Groups

International Journal of Endocrinology, 2019
Introduction. The blood irisin concentrations may be affected both by exercise and pregnancy. We aimed to determine acute responses in serum irisin after a single exercise session and relationships between exercise-induced changes in this hormone and ...
Anna Szumilewicz, Aneta Worska, Magdalena Piernicka, Agnieszka Kuchta, Zbigniew Jastrzębski, Łukasz Radzimiński, Marta Kozłowska, Katarzyna Micielska, Ewa Ziemann   +8 more
doaj   +1 more source