Results 61 to 70 of about 104,124 (265)

Baseline cognitive performance moderates ACL injury–related knee biomechanics during unanticipated sidestep cutting in highly trained male soccer players

Frontiers in Physiology
ObjectiveTo compare anterior cruciate ligament (ACL) injury–related knee biomechanics between anticipated and unanticipated sidestep cutting and to investigate whether baseline cognitive performance moderated these biomechanical responses in highly ...
Weipeng Liu, Zilong Wang, Zhuangzhuang Wang, Zhiyuan Qin, Zhengwei Wu, Weihua Zheng, Congjie Cheng, Weichao Li, Wenhua Li   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Analysis of kinematic factors influencing performance in the Chinese men’s 4 × 100 m relay team

Scientific Reports
To investigate the key factors influencing performance in the men’s 4 × 100 m relay, this study analyzed the relationship between baton exchange kinematics and relay zone performance.
Zhao Li, Caizheng Yue, Zhen Li, Xicheng Wang, Haokai Xu, Zhongshuo Zhao, Keli Deng   +6 more
doaj   +1 more source

Effects of multi-ingredient protein supplementation combined with exercise intervention on body composition and muscle fitness in healthy women: a systematic review with multilevel meta-analysis

Frontiers in Nutrition
ObjectivesThis meta-analysis investigated whether multi-ingredient protein supplements (MIPS) combined with exercise improve body composition and muscle fitness in women.
Chengyu Zhou, Muen Qiu, Zhuo Zeng, Qi Xie, Kai Xu, Kai Xu, Henghao Yan, Bo Wang, Bopeng Qiu, Guoxin Shi   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Acute caffeine supplementation in rugby players: a systematic review and meta-analysis of physical performance, sport-specific performance, perceptual responses, and physiological markers

Frontiers in Nutrition
BackgroundRugby is a collision-based team sport requiring repeated high-intensity sprinting, technical execution, and physical contact under fatigue. Although caffeine is used as an ergogenic supplement, evidence from mixed team-sport populations may not
Jun Li, Dawei Zhou, Tianle Wang, Zeyong Liu, Zhuo Zeng, Caizheng Yue, Cong Huang, Weixin Chen, Junyi Shu, Fanhao Meng   +9 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Effects of Recreational Football on Body Composition and Cardiometabolic Health in Overweight or Obese Individuals: A Systematic Review and Meta-Analysis

Life
Objective: This study systematically examined the effects of recreational football on body composition and cardiometabolic health in overweight or obese individuals via subgroup analyses of potential moderators. Methods: A systematic search was conducted
Sijia Li, Haoran Li, Bo Wang, Zhuo Zeng, Rui Zhang, Henghao Yan, Aiguo Zhou, Yongmin Xie, Chengyu Zhou   +8 more
doaj   +1 more source