Results 71 to 80 of about 108,631 (219)

Physical Conditioning Strategies for the Prevention of Concussion in Sport: a Scoping Review. [PDF]

Sports Med Open, 2021
Garnett D, Patricios J, Cobbing S.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Soldier Load Carriage, Injuries, Rehabilitation and Physical Conditioning: An International Approach. [PDF]

Int J Environ Res Public Health, 2021
Orr R, Pope R, Lopes TJA, Leyk D, Blacker S, Bustillo-Aguirre BS, Knapik JJ.   +6 more
europepmc   +1 more source

Effects of exercise in people with multiple sclerosis: a systematic review and meta-analysis

Frontiers in Public Health
BackgroundA growing body of studies have examined the effect of exercise in people with multiple sclerosis (MS), while findings of available studies were conflicting. This meta-analysis aimed to explore the effects of exercise on balance, walking ability,
Liwen Du, Liwen Du, Haoyu Xi, Haoyu Xi, Shiyan Zhang, Yilun Zhou, Xifeng Tao, Yuanyuan Lv, Xiao Hou, Xiao Hou, Laikang Yu, Laikang Yu   +11 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effects of nutritional supplementation combined with exercise on BMI and lipid profiles in individuals with overweight or obesity: a systematic review and meta-analysis

Frontiers in Nutrition
BackgroundThis study systematically evaluated the effects of nutritional supplementation combined with exercise on BMI and lipid profiles in individuals with overweight or obesity.MethodsA systematic search was conducted in PubMed, Embase, Web of Science,
Hongling Cheng, Chengyu Zhou, Shiwei Song, Bo Wang, Diandong Lang, Peng Sun   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Efficacy and moderators of isometric resistance training (IRT) on resting blood pressure among patients with pre- to established hypertension: a multilevel meta-review and regression analysis

BMC Sports Science, Medicine and Rehabilitation
Objective This study aims to evaluate the efficacy of isometric resistance training (IRT) in lowering blood pressure through meta-analyses, specifically systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), in ...
Chengyu Zhou, Sijia Li, Zengyu Zhang, Jiamin Chen, Jian Song, Yongmin Xie, Zhuolin Tang, Aiguo Zhou   +7 more
doaj   +1 more source