Results 81 to 90 of about 10,751,784 (367)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Internal motivation for training of students of specialty "Physical culture and sports" [PDF]

, 2000
У статті розглянуто питання внутрішньої мотивації студентів до навчання, проаналізовано поняття мотивації та внутрішньої мотивації, визначено рівень мотивації до навчання у студентів та розглянуто більш детальне відношення до дисциплін студентів ...
Höcker, Hartwig, Karrie, S., Körner, Andrea   +2 more
core   +1 more source

Use of special exercises for the development of motor qualities and the formation of technical and tactical actions of defenders 13–14 years in the preparatory period

Слобожанський науково-спортивний вісник, 2019
Purpose: to develop the content of training programs for the extreme and central defenders using special exercises in accordance with the game role and determine the effectiveness of their use in young football players 13–14 years old. Material & Methods:
Yaroslav Kraynik, Vyacheslav Mulik, Daria Okun , Svyatoslav Koval   +3 more
doaj   +1 more source

Physical condition of pupils of pre-school educational establishments of different types

Pedagogy of Physical Culture and Sports, 2020
The purpose of the study is to determine the physical condition of the pupils of pre-school educational establishments of various types for improving the quality of the educational process of physical education. Material and methods .
N.V. Moskalenko, V.G. Savchenko, A.V. Polyakova, O.S. Mikitchik, O.O. Mitova, V.V. Griukova, A.V. Mytsak   +6 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Perfection of badminton players’ speed-power fitness with the help of training means’ variable modules

Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2016
Purpose: to determine effectiveness of badminton players’ speed power fitness program’s perfection at stage of specialized basic training with different variants of training means modules’ combination.
I.V. Karatnyk, O.O. Hrechanyuk, O.Y. Bubela, M.P. Pityn   +3 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Effectiveness of physical therapy for autonomic dysfunction in adolescents

Слобожанський науково-спортивний вісник, 2020
Purpose: based on the generalization of the results of modern domestic and foreign scientific and methodological literature to develop a physical therapy program for adolescents with autonomic dysfunction.
Katerina Sobolenko, Oleksii Honcharov, Andreii Litovchenko, Larysa Zhykova   +3 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source