Results 91 to 100 of about 24,730,233 (347)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The use of the Snake Ladder Board Physical Education to enhance the physical literacy of elementary students

Sriwijaya Journal of Sport
Research Problems: Innovative instructional media are needed to enhance student engagement and promote physical literacy in elementary Physical Education (PE). Board game-based learning offers an interactive approach that integrates cognitive, affective,
Fina Junianti, Selvi Atesya Kesumawati, Dewi Septaliza, Bayu Hardiyono, Aprizal Fikri, Selvi Melianty, Muslimin Muslimin, Husni Fahritsani   +7 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Lack of Intensity Control during an Exercise Program Is Related to a Limited Effect on Variables Responsible for Blood Pressure Regulation in Hypertensive Older Adults

Journal of Aging Research
To compare the effect of an intensity-controlled exercise program (ICEP) and a nonintensity-controlled exercise program (non-ICEP) on the variables responsible for blood pressure regulation in hypertensive older adults.
Roberta Fernanda da Silva, Thaís Amanda Reia, André Mourão Jacomini, Anderson Bernadino da Silva, Henrique dos Santos Disessa, Henrique Luiz Monteiro, Anderson Saranz Zago   +6 more
doaj   +1 more source

Comparison of visceral fat lipolysis adaptation to high-intensity interval training in obesity-prone and obesity-resistant rats

Diabetology & Metabolic Syndrome, 2022
Background/objectives Visceral obesity is one of the key features of metabolic syndrome. High-intensity interval training (HIIT) could effectively reduce visceral fat, but its effects show strong heterogeneity in populations with different degrees of ...
Yang Liu, Yu Li, Baishuo Cheng, Shige Feng, Xiangui Zhu, Wei Chen, Haifeng Zhang   +6 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Developmentally Appropriate Health in Physical Education

, 2014
With the aim of building fundamental movement concepts for a strong foundation for the facilitation of skill acquisition, a ‘skill theme’ approach is presented.
Physical Education Matters, Murray, A., Murray, Pamela   +2 more
core   +2 more sources

The effectiveness of digital health intervention on glycemic control and physical activity in patients with type 2 diabetes: a systematic review and meta-analysis

Frontiers in Digital Health
IntroductionDigital health interventions (DHIs) offer promising strategies for managing type 2 diabetes mellitus (T2DM), yet their efficacy on physical activity remains inconsistent.
Haoyuan Xue, Lin Zhang, Yarong Shi, Hao Zhang, Chuanrong Zhang, Yang Liu, Wenshu Tan, Yaorong Liu, Yaorong Liu   +8 more
doaj   +1 more source