Results 51 to 60 of about 151,857 (212)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Work addiction, emotional dysregulation, addictive eating, and physical health among full-time employees in the United States

Frontiers in Psychology
Background and aimsThis study explored the psychological mechanisms linking work addiction to poor physical health among full-time employees. The proposed serial multiple mediation model suggests that work addiction depletes employees’ ability to ...
Catherine So-Kum Tang
doaj   +1 more source

C-Reactive Protein as a Peripheral Biomarker in Schizophrenia. An Updated Systematic Review

Frontiers in Psychiatry, 2018
Objectives: The objective of this systematic review was to synthetize the published data on the relationships between elevated blood C-reactive protein (CRP) levels and schizophrenia (SZ) onset risk, illness characteristics and treatments, cognition and ...
Guillaume Fond, Christophe Lançon, Pascal Auquier, Laurent Boyer   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Persistent Social Inequality in Adolescent Health Indicators 1991–2022: Trend Study From Denmark

International Journal of Public Health
ObjectivesTo examine trends in socioeconomic inequality in adolescent health over three decades, across fifteen health indicators: overweight, underweight, headache, stomachache, backpain, emotional symptoms, difficulties falling asleep, loneliness, low ...
Bjørn E. Holstein, Mogens Trab Damsgaard, Trine Pagh Pedersen, Mette Rasmussen, Julie Ellegaard Ibáñez Román, Mette Toftager, Katrine Rich Madsen   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Urban Green Spaces and Healthy Living: A Landscape Architecture Perspective

Urban Science
This paper examines the essential role of urban green spaces in fostering healthy living from a landscape architecture perspective. Health goes beyond the mere absence of disease to include physical, mental, and social wellbeing, all of which are greatly
Alessio Russo
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Providing Physical Health Checks for People with Severe Mental Illness in Primary Care in England: An Evaluation of a Locally Enhanced Service

Nursing Reports
Background/Objectives: People with a severe mental illness die much earlier than the rest of the population from a preventable physical illness.
Sheila Hardy
doaj   +1 more source