Results 91 to 100 of about 6,557,344 (291)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The Concept of The Integrity of the Person and Neurorights: A Review of Controversial Issues

Московский журнал международного права
INTRODUCTION. The article examines the evolution of the concept of the integrity of the person in international law. An analysis of universal and regional international legal acts, as well as cases considered by international judicial and quasi-judicial ...
J. M. Aliyev
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Lineage-specific CDK activity dynamics characterize early mammalian development

Cell Reports
Summary: Cyclin-dependent kinases (CDKs) regulate proliferation dynamics and cell fate in response to extracellular inputs. It remains largely unknown how CDK activity fluctuates and influences cell commitment during early mammalian development. Here, we
Bechara Saykali, Andy D. Tran, James A. Cornwell, Matthew A. Caldwell, Paniz Rezvan Sangsari, Nicole Y. Morgan, Michael J. Kruhlak, Steven D. Cappell, Sergio Ruiz   +8 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Secure Physical Enclosures from Covers with Tamper-Resistance

Transactions on Cryptographic Hardware and Embedded Systems, 2018
Ensuring physical security of multiple-chip embedded systems on a PCB is challenging, since the attacker can control the device in a hostile environment.
Vincent Immler, Johannes Obermaier, Kuan Kuan Ng, Fei Xiang Ke, JinYu Lee, Yak Peng Lim, Wei Koon Oh, Keng Hoong Wee, Georg Sigl   +8 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Evaluating the green credentials and performance of deep eutectic solvents in the extraction of antibiotics and mycotoxins in foods

Green Chemistry Letters and Reviews
Deep eutectic solvents (DES) are new generation solvents that have recently emerged as a sustainable alternative to organic solvents in the extraction of chemical contaminants in foods.
Oluwatobi Kolawole, Chongdee Thammakhet-Buranachai, Awanwee Petchkongkaew, Thanasat Sooksimuang, Christopher Elliott, Nitsara Karoonuthaisiri   +5 more
doaj   +1 more source

Constructing Artistic Integrity: An Exploratory Study [PDF]

, 2006
This thesis explores the concept of artistic integrity. A historical foundation for artistic integrity is laid to provide a context within which eight artists' constructions of the concept can be placed.
Barbour, Kim Jaime
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source