Results 51 to 60 of about 6,557,344 (291)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Prevalence and associated factors of interpersonal violence in organized sport in a population-based sample of Quebec (Canada) adolescents: a cross-sectional study

The Lancet Regional Health. Americas
Summary: Background: Previous studies usually examine interpersonal violence (IV) in sport using convenience samples, potentially biasing exposure estimates. This study aimed to estimate IV prevalence and identify associated factors in a population-based
Sylvie Parent, Martin Blais, Allyson Gillard, Emilie Belley-Ranger, Stephanie Radziszewski, Sophie Labossière, Isabelle Daignault, Jacinthe Dion, Martine Hébert, Tine Vertommen, Jean-Michel Galarneau   +10 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

White Matter Integrity Underlies the Physical-Cognitive Correlations in Subjective Cognitive Decline

Frontiers in Aging Neuroscience, 2021
Objective: Although previous studies postulated that physical and cognitive decline codeveloped in preclinical dementia, the interconnected relationship among subjective cognitive complaints (SCCs), objective cognitive performance, and physical activity ...
Yi-Chia Wei, Yi-Chia Wei, Yi-Chia Wei, Chih-Chin Heather Hsu, Chih-Chin Heather Hsu, Wen-Yi Huang, Wen-Yi Huang, Wen-Yi Huang, Yao-Liang Chen, Yao-Liang Chen, Chemin Lin, Chemin Lin, Chemin Lin, Chih-Ken Chen, Chih-Ken Chen, Chih-Ken Chen, Chen Lin, Yu-Chiau Shyu, Yu-Chiau Shyu, Yu-Chiau Shyu, Ching-Po Lin, Ching-Po Lin, Ching-Po Lin, Ching-Po Lin   +23 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Global Integrity Report: Israel [PDF]

, 2007
This peer-reviewed country report includes:Integrity Indicators Scorecard: Scores, scoring criteria, commentary, references, and peer review perspectives for all 290 Integrity Indicators.Reporter's Notebook: An on-the-ground look at corruption and ...

core   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Physical education down under: Fusion or confusion [PDF]

, 2007
At the International Council for Health, Physical Education, Recreation, Sport and Dance (ICHPER-SD) Conference held in Wellington in October 2006, the authors presented a keynote titled: Physical Education Down Under: Fusion or Confusion.
Culpan, Ian, Grant, Bevan C.
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source