Results 131 to 140 of about 8,811,391 (311)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Cyber-physical distributed systems modeling, reliability analysis and applications

open access: yes, 2021
CYBER-PHYSICAL DISTRIBUTED SYSTEMSGather detailed knowledge and insights into cyber-physical systems behaviors from a cutting-edge reference written by leading voices in the fieldIn Cyber-Physical Distributed Systems: Modeling, Reliability Analysis and ...
Xie, Min 1963-   +2 more
core  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Review on the Modeling of Electrostatic MEMS

open access: yes, 2010
Electrostatic-driven microelectromechanical systems devices, in most cases, consist of couplings of such energy domains as electromechanics, optical electricity, thermoelectricity, and electromagnetism.
Pei-Zen Chang   +7 more
core   +2 more sources

Mathematical and Physical Modeling Principles of Complex Biological Systems

open access: yes, 2019
A model of a complex system is a facsimile that can be used to investigate the problem at hand by simulating its behavior under specific conditions. Many modeling approaches are used in the applied sciences, including physical, animal, conceptual, and ...
Sacco R., Guidoboni G., Mauri A. G.
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

open access: yesFEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés   +2 more
wiley   +1 more source

Physical Modeling Modular Boxes: PHOXES [PDF]

open access: yes, 2010
This paper presents the development of a set of musical instruments, which are based on known physical modeling sound synthesis techniques. The instruments are modular, meaning that they can be combined in various ways.
Gelineck, Steven   +1 more
core  

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

open access: yesFEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini   +3 more
wiley   +1 more source

Investigating Two-dimensional Horizontal Mesh Grid Effects on the Eulerian Atmospheric Transport Model Using Artificial Neural Network

open access: yesAerosol and Air Quality Research
The complexity of monitoring is compounded by the environmental and health impacts linked to air pollution. The elevated expenses and intricate execution involved in measurements prompt the integration of modeling as a complementary approach alongside ...
Amine Ajdour   +9 more
doaj   +1 more source

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