Results 111 to 120 of about 8,228,052 (313)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Blind Separation of Skin Chromophores from Multispectral Dermatological Images
DiagnosticsBackground/Objectives: Based on Blind Source Separation and the use of multispectral imaging, the new approach we propose in this paper aims to improve the estimation of the concentrations of the main skin chromophores (melanin, oxyhemoglobin and ...
Mustapha Zokay, Hicham Saylani
doaj +1 more source
Interharmonics: Theory and Modeling
, 2007 Some of the most remarkable issues related to interharmonic theory and modeling are presented. Starting from the basic definitions and concepts, attention is first devoted to interharmonic sources.
IEEE TASK FORCE ON HARMONICS MODELING a. S. +2 more
core +1 more source
Renormalization group for link percolation on planar hyperbolic manifolds [PDF]
, 2019 Network geometry is currently a topic of growing scientific interest, as it opens the possibility to explore and interpret the interplay between structure and dynamics of complex networks using geometrical arguments.
Mathematical Modeling +7 more
core +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The hunt for canards in population dynamics: A predator-prey system [PDF]
, 2014 Equations with periodic coefficients for singularly perturbed growth can be analysed by using fast and slow timescales which involves slow manifolds, canards and the dynamical exchanges between several slow manifolds.
Mathematical Modeling +2 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
University research: From physical modeling to journal paper writing
, 2009 Monday, June 22, 9-13 Fluid Mechanics modeling Motivation Scaling laws Possibilities Limitations Examples Tuesday, June 23 9-13 Scour and impulse waves in hydraulic engineering Issues of scour Plunge pool scour Pier scour Engineering ...
PULCI DORIA, GUELFO
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Results in PhysicsThe evolution of a polydisperse ensemble of prolate and oblate ellipsoidal crystals in a supercooled one-component melt is theoretically studied. The volume growth rates for prolate and oblate ellipsoids are analytically found and compared at the same ...
Dmitri V. Alexandrov +4 more
doaj +1 more source