Results 81 to 90 of about 459,443 (269)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Phase synthesis method in multi-aperture optical systems based on iterative image processing algorithms

Физика волновых процессов и радиотехнические системы
Background. Modern technologies in the field of optics and photonics place high demands on the quality and output power of the radiation source. The fulfillment of these requirements can currently be achieved by creating multi-aperture laser systems with
Petr A. Semenov, Viacheslav V. Zemlyakov, Svetlana A. Vyatkina   +2 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Scattering spectra models for physics

PNAS Nexus
Abstract Physicists routinely need probabilistic models for a number of tasks such as parameter inference or the generation of new realizations of a field. Establishing such models for highly non-Gaussian fields is a challenge, especially when the number of samples is limited.
Sihao Cheng, Rudy Morel, Erwan Allys, Brice Ménard, Stéphane Mallat   +4 more
openaire   +4 more sources

Determination of Operating Parameters of Mobile Snow Melting Plant

Вестник СибАДИ
Introduction. Clearing the territories of populated areas from fallen snow in winter is an urgent task. Its effective solution is necessary to ensure road safety and mobility.
Anatoliy A. Serebrennikov, Andrey A. Plokhov   +1 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

A Physical Model of the Reeb Foliation

Axioms
In this paper, after explaining some basic aspects of the modern theory of foliations with the aim of describing the celebrated Reeb foliation, we propose the first construction of a comprehensive physical model of it. The construction of the model is achieved through an implementation of geometric methods for 3D printing.
Bande, Gianluca, Franzoni, Gregorio
openaire   +2 more sources

Investigating Two-dimensional Horizontal Mesh Grid Effects on the Eulerian Atmospheric Transport Model Using Artificial Neural Network

Aerosol and Air Quality Research
The complexity of monitoring is compounded by the environmental and health impacts linked to air pollution. The elevated expenses and intricate execution involved in measurements prompt the integration of modeling as a complementary approach alongside ...
Amine Ajdour, Brahim Ydir, Houria Bouzghiba, Ishaq Dimeji Sulaymon, Anas Adnane, Dris Ben Hmamou, Kenza Khomsi, Jamal Chaoufi, Gábor Géczi, Radouane Leghrib   +9 more
doaj   +1 more source