Results 91 to 100 of about 8,811,391 (311)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

CFD Simulation of Pollutant Emission in a Natural Draft Dry Cooling Tower with Flue Gas Injection: Comparison between LES and RANS

Energies, 2019
Accurate prediction of pollutant dispersion is vital to the energy industry. This study investigated the Computational Fluid Dynamics (CFD) simulation of pollutant emission in a natural draft dry cooling tower (NDDCT) with flue gas injection. In order to
Guangjun Yang, Xiaoxiao Li, Li Ding, Fahua Zhu, Zhigang Wang, Sheng Wang, Zhen Xu, Jingxin Xu, Pengxiang Qiu, Zhaobing Guo   +9 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Physical simulation of glacier motion modes

Лëд и снег, 2016
Modes of «dry friction» at glacier-bedrock interface (ice sliding and flow) were simulated under uniform compression with different combinations of mechanical and thermodynamic factors.
V. P. Epifanov
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Aluminum doped zinc oxide nanoplatelets based sensor with enhanced hydrogen sulfide detection

Scientific Reports
This study explores the development of highly sensitive hydrogen sulfide (H2S) gas sensors employing hierarchical aluminum-doped zinc oxide (AZO) nanostructures.
Brahim Ydir, Amine Ajdour, Iulia Antohe, Gabriel Socol, Marcela Socol, Luiza-Izabela Toderascu, Driss Saadaoui, Imade Choulli, Radouane Leghrib, Houda Lahlou   +9 more
doaj   +1 more source

Gromologist: A GROMACS-oriented utility library for structure and topology manipulation

SoftwareX
Despite the increasing automation of workflows for the preparation of systems for molecular dynamics simulations, the custom editing of molecular topologies to accommodate non-standard modifications remains a daunting task even for experienced users.
Miłosz Wieczór, Jacek Czub, Modesto Orozco   +2 more
doaj   +1 more source

Tectonophysical approach to the analysis of geological and geophysical data on gas-condensate deposits with the complex platform cover

Геодинамика и тектонофизика, 2018
The article presents the results of the tectonophysical approach to the analysis of stress fields and the structure of gas–condensate deposits with the complex platform cover. The discussed case is the Kovykta license area (LA) in Eastern Siberia, Russia.
K. Zh. Seminsky, V. A. Sankov, V. V. Ogibenin, Yu. P. Burzunova, A. I. Miroshnichenko, E. A. Gorbunova, I. V. Gorlov, A. S. Smirnov, A. G. Vakhromeev, I. V. Buddo   +9 more
doaj   +1 more source

Feasibility of Detailed Vehicle Modeling [PDF]

, 2001
A feasibility study is presented concerning detailed vehicle modeling, including submodels for engine, transmission mechanics and hydraulics, as well as three-dimensional chassis behavior.
Michael Tiller, Paul Bowles, Otter, Martin, Tiller, Michael, Mattsson, Sven Erik, Dag Brück, Brück, Dag, Andreas Möller, Hans Olsson, Sven Erik Mattsson, Hilding Elmqvist, Bowles, Paul, Elmqvist, Hilding, Martin Otter, Möller, Andreas, Olsson, Hans   +15 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source