Results 111 to 120 of about 8,177,099 (212)
Aerosol and Air Quality ResearchThe complexity of monitoring is compounded by the environmental and health impacts linked to air pollution. The elevated expenses and intricate execution involved in measurements prompt the integration of modeling as a complementary approach alongside ...
Amine Ajdour +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Block-based physical modeling with applications in musical acoustics [PDF]
, 2008 Block-based physical modeling is a methodology for modeling physical systems with different subsystems. Each subsystem may be modeled according to a different paradigm.
Rabenstein, R., Petrausch, S.
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Schematic Modeling for Simulation of Physical Systems [PDF]
, 1990 This paper proposes a method for classifying and implementing schematic representation in multiple domains within a simulation system. Our initial work is restricted to the modeling of rigid components for kinematic and dynamic simulations. We hope to
Yang, Xue Dong
core +2 more sources
Symposium on Solid and Physical Modeling
, 2016 Botsch M, Hahmann S, Schaefer S, eds. Symposium on Solid and Physical Modeling. Computer Aided Design.
Hahmann, Stefanie +2 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Research on eco-hydro-morphological river processes by combining field investigations, physical modeling and numerical simulations [PDF]
Hydrodynamical, morphodynamical and ecological river processes and their multiple linkages occur in an infinity of different configurations and over a wide range of spatial and temporal scales.
Blanckaert, Koen +11 more
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source