Results 81 to 90 of about 8,177,099 (212)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Tools for Semi-Physical Modeling

, 1994
By semi-physical modeling we mean such an application of system identification, where physical insight into the application is used to come up with suitable nonlinear transformations of the raw measurements, so as to allow for a good model structure ...
Ljung, Lennart,, Lindskog, Peter,
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Using Rasch modeling to re-evaluate three scales related to physical activity: Enjoyment, perceived benefits and perceived barriers [PDF]

, 2006
Studies suggest that enjoyment, perceived benefits and perceived barriers may be important mediators of physical activity. However, the psychometric properties of these scales have not been assessed using Rasch modeling.
Masse, L.C., Dunn, A., Heesch, K. C., Dunn, A.L., Heesch, Kristiann, Masse, Louise   +5 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Blind Separation of Skin Chromophores from Multispectral Dermatological Images

Diagnostics
Background/Objectives: Based on Blind Source Separation and the use of multispectral imaging, the new approach we propose in this paper aims to improve the estimation of the concentrations of the main skin chromophores (melanin, oxyhemoglobin and ...
Mustapha Zokay, Hicham Saylani
doaj   +1 more source

Physical system modeling with Modelica

, 1998
A new language Modelica, for the modeling of physical systems has been developed in an international effort. The main objective was to make it easy to exchange models and model libraries.
Sven Erik Mattsson, Hilding Elmqvist, Mattsson, S. E., Martin Otter, Otter, M., Elmqvist, H.   +5 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The Study of Geomechanical Condition of Unstable Rocks in the Vicinity of Mine Working Junctions

Горные науки и технологии, 2019
The relevance of research of material strain nature based on physical models equivalent to rocks is substantiated. To identify the dependencies and mechanism of unstable rock strain in the vicinity of mine working junctions, an experimental technique has
V. V. Basov
doaj   +1 more source

Physical modeling versus numerical modeling

, 2003
Despite the widespread use of numerical modeling, there is still room for physical modeling today for many reasons. E.g., physical modeling is based on real wave propagation whereas numerical modeling is based on algorithms which are by necessity ...
Veldhuizen, E. van, Blacquière, G.
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