Results 141 to 150 of about 8,811,391 (311)
HEMOS-Cloud: HPC Cloud-based Modeling and Simulation Platform for HEMOS Software
, 2017 Modeling & Simulation (M&S) is a technology that replaces the physical productionand experimentation of products with virtual production (modeling) and engineeringanalysis (simulation).
김명일 +3 more
core
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Block-based physical modeling with applications in musical acoustics [PDF]
, 2008 Block-based physical modeling is a methodology for modeling physical systems with different subsystems. Each subsystem may be modeled according to a different paradigm.
Rabenstein, R., Petrausch, S.
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Symposium on Solid and Physical Modeling
, 2016 Botsch M, Hahmann S, Schaefer S, eds. Symposium on Solid and Physical Modeling. Computer Aided Design.
Hahmann, Stefanie +2 more
core
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Research on eco-hydro-morphological river processes by combining field investigations, physical modeling and numerical simulations [PDF]
Hydrodynamical, morphodynamical and ecological river processes and their multiple linkages occur in an infinity of different configurations and over a wide range of spatial and temporal scales.
Blanckaert, Koen +11 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Numerical and physical modeling of breast cancer based on image fusion and artificial intelligence. [PDF]
Breast Cancer Res Treat, 2023 Dołęga-Kozierowski B +11 more
europepmc +1 more source