Results 141 to 150 of about 581,628 (317)

Numerical and Physical Modeling of Liquid Steel Asymmetric Behavior during Non-Isothermal Conditions in a Two-Strand Slab Tundish-"Butterfly Effect". [PDF]

Materials (Basel), 2023
Cwudziński A, Pieprzyca J, Merder T.
europepmc   +1 more source

Physical system modeling with Modelica

, 1998
A new language Modelica, for the modeling of physical systems has been developed in an international effort. The main objective was to make it easy to exchange models and model libraries.
Sven Erik Mattsson, Hilding Elmqvist, Mattsson, S. E., Martin Otter, Otter, M., Elmqvist, H.   +5 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Physical modeling and geometric shape simulation for one-dimensional flexible objects with cylindrical surface constraints. [PDF]

Sci Rep, 2023
Mei Y, Du H, Jiang Q, Xiong W.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The Effect of Lateral Loading Parameters on Monopile Behavior Based on Physical Modeling

نشریه مهندسی دریا, 2019
Monopiles are the most common type of foundation for offshore wind turbines (OWT). Monopiles have been used in more than 80% of the offshore wind turbines.
Mahdi Shahidikhah, Majid Moradi, Alireza Khamseh   +2 more
doaj  

Physical modeling of ribosomes along messenger RNA: Estimating kinetic parameters from ribosome profiling experiments using a ballistic model. [PDF]

PLoS Comput Biol, 2023
Chevalier C, Dorignac J, Ibrahim Y, Choquet A, David A, Ripoll J, Rivals E, Geniet F, Walliser NO, Palmeri J, Parmeggiani A, Walter JC.   +11 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Experimental and Numerical Study of Tension Bearing Capacity of Circular Skirted Foundations Resting on Sand Bed

نشریه مهندسی دریا, 2019
Skirted foundations are an appropriate alternative to deep foundations in onshore and offshore structures, which have the ability to withstand uplift loads, are also easy to be installed. The tensile performance of skirted foundations on sand was studied
Sajjad Gholipour, Masoud Makarchian
doaj  

Inception of Constructional Submarine Conduit by Asymmetry Generated by Turbidity Current

Journal of Marine Science and Engineering
Submarine conduits are features responsible for transporting clastic debris from continents to the deep ocean. While the architecture of conduits has been extensively studied, the process of their inception remains unclear.
Daniel Bayer da Silva, Eduardo Puhl, Rafael Manica, Ana Luiza de Oliveira Borges, Adriano Roessler Viana   +4 more
doaj   +1 more source