Physical modeling of ribosomes along messenger RNA: Estimating kinetic parameters from ribosome profiling experiments using a ballistic model. [PDF]
PLoS Comput Biol, 2023 Chevalier C +11 more
europepmc +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Physical Modeling of the Impeller Construction Impact on the Aluminum Refining Process. [PDF]
Materials (Basel), 2022 Saternus M, Merder T.
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Development of Preliminary Precision Forging Technology and Concept for Tools Used to Reforge 60E1A6 Profile Needle Rails with the Use of Numerical and Physical Modeling. [PDF]
Materials (Basel), 2023 Hawryluk M +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Integrated Physical Modeling and Optimal Control Method of Limited-Angle Torque Motor in Fuel Metering Apparatus. [PDF]
Micromachines (Basel), 2022 Chen Q, Sheng H, Jiang S.
europepmc +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
The Effect of Lateral Loading Parameters on Monopile Behavior Based on Physical Modeling
نشریه مهندسی دریا, 2019 Monopiles are the most common type of foundation for offshore wind turbines (OWT). Monopiles have been used in more than 80% of the offshore wind turbines.
Mahdi Shahidikhah +2 more
doaj
Correction: A prediction tool for plaque progression based on patient-specific multi-physical modeling. [PDF]
PLoS Comput Biol, 2021 Pan J +6 more
europepmc +1 more source