Results 91 to 100 of about 8,708,690 (320)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Brain inspired iontronic fluidic memristive and memcapacitive device for self-powered electronics

Microsystems & Nanoengineering
Ionic fluidic devices are gaining interest due to their role in enabling self-powered neuromorphic computing systems. In this study, we present an approach that integrates an iontronic fluidic memristive (IFM) device with low input impedance and a ...
Muhammad Umair Khan, Bilal Hassan, Anas Alazzam, Shimaa Eissa, Baker Mohammad   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Characteristics of back pain in Polish youth depending on place of residence

Annals of Agricultural and Environmental Medicine, 2014
[b]Introduction and objective[/b]. Spinal pain (SP) has become a very common problem in contemporary societies and occurs in adults, youths, and even children.
Jacek Lewandowski, Kornelia Łukaszewska   +1 more
doaj  

Dynamical noncommutativity

, 2009
The model of dynamical noncommutativity is proposed. The system consists of two interrelated parts. The first of them describes the physical degrees of freedom with coordinates q^1, q^2, the second one corresponds to the noncommutativity r which has a ...
A J da Silva, Adorno T C Baldiotti M C Chaichian M Gitman D M Tureanu A, Amelino-Camelia G, Bopp F, Duval C, Horvathy P A, Landau L D, M Gomes, Seiberg N, Szabo R, V G Kupriyanov   +10 more
core   +3 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Midlatitude mesoscale thermal Air-sea interaction enhanced by greenhouse warming

Nature Communications
The influence of greenhouse warming on mesoscale air-sea interactions, crucial for modulating ocean circulation and climate variability, remains largely unexplored due to the limited resolution of current climate models.
Xiaohui Ma, Xingzhi Zhang, Lixin Wu, Zhili Tang, Peiran Yang, Fengfei Song, Zhao Jing, Hui Chen, Yushan Qu, Man Yuan, Zhaohui Chen, Bolan Gan   +11 more
doaj   +1 more source

Task-oriented Communication Design in Cyber-Physical Systems: A Survey on Theory and Applications [PDF]

, 2021
Arsham Mostaani, Thang X. Vu, Shree Krishna Sharma, Qi Liao, Symeon Chatzinotas, Chatzinotas, Symeon   +5 more
openalex   +1 more source