Results 51 to 60 of about 314,330 (303)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

THE ROLE OF THE PHYSIOTHERAPIST IN PALLIATIVE CARE IN ONCOLOGY PATIENTS: A SYSTEMATIC REVIEW

open access: yesJournal of Cancer Rehabilitation
Background Physiotherapy in palliative oncology patients is less discussed in literature and needs to be thoroughly investigated. Aim The aim of this study was to gather and analyze the available evidence on the effect of physiotherapy in oncology ...
Luna Gauchez, PT   +7 more
doaj   +1 more source

A pilot study evaluating the effect of early physical therapy on pain and disabilities after breast cancer surgery: Prospective randomized control trail

open access: yesBreast, 2021
Background: Morbidity of the shoulders after breast cancer (BC) surgery is a common side effect that includes; persistent pain, function limitation, and decreased range of motion (ROM).
Ifat Klein   +3 more
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito   +14 more
wiley   +1 more source

The Pairing of Trigger Point Dry Needling with Rehabilitation Techniques [PDF]

open access: yes, 2019
Trigger point dry needling is a manual treatment modality used for individuals experiencing tightness, pain, and inhibited range of motion in any region of the body.
Kotze, Karle
core   +1 more source

Diagnostic modalities and physical therapy in patients with Carpal tunnel syndrome

open access: yesMedicinski podmladak, 2022
Carpal tunnel syndrome (CTS) represents one of the most common compressive peripheral neuropathies on the upper extremities, and is characterized by compression of the medial nerve on its way through the carpal tunnel area. The first changes experienced by patients with CTS are sensory and occur mainly at night, and if they are not recognized and ...
Darko Bulatović, Dejan Nikolić
openaire   +2 more sources

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall   +16 more
wiley   +1 more source

Training for muscular power adaptations : the role of contraction type and velocity [PDF]

open access: yes, 2016
Muscular power, an integral component in most sport, is the product of force and velocity. Power is often viewed as synonymous, yet incorrectly, with strength. Where power has an inherent speed component, strength is independent of movement velocity, and
Brenneman, Michael Travis
core   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang   +8 more
wiley   +1 more source

Today\u27s Fibromyalgia [PDF]

open access: yes, 2019
Fibromyalgia is a chronic musculoskeletal disorder which results in widespread pain, fatigue, cognitive difficulties, and emotional distress (CDC, 2017). It is also associated with abnormal pain processing.
Glennon, McKenzie K.
core   +1 more source

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