Results 41 to 50 of about 9,629,107 (280)

Finite Element Analysis of Protective Measures against Lateral Hinge Fractures in High-Tibial Osteotomy

Advances in Orthopedics
Background. Opening wedge high-tibial osteotomy (OWHTO) is widely used for correcting mechanical axis deviations and offloading the medial compartment in unicompartmental osteoarthritis.
Emre Özmen, Alican Baris, Esra Circi, Serdar Yuksel, Ozan Beytemür   +4 more
doaj   +1 more source

Endocrine Responses to Physical Training and Tribulus Terrestris Supplememtation in Middle-Age Men

Central European Journal of Sport Sciences and Medicine, 2016
The aim of this study was to evaluate the effects of steroidal saponin supplementation on blood concentration of T, GH and IGF-1. The research involved 14 men between the age of 45 and 60 years. The duration of the experiment was 12 weeks. There were two
Jakub Chycki, Miłosz Czuba, Artur Gołaś, Adam Maszczyk, Małgorzata Michalczyk, Robert Roczniok, Robert Roczniok, Michał Wilk, Adam Zając, Adam Zając   +9 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Training of physical neural networks

Nature
Physical neural networks (PNNs) are a class of neural-like networks that leverage the properties of physical systems to perform computation. While PNNs are so far a niche research area with small-scale laboratory demonstrations, they are arguably one of the most underappreciated important opportunities in modern AI.
Momeni, Ali, Rahmani, Babak, Scellier, Benjamin, Wright, Logan, Mcmahon, Peter, Wanjura, Clara, Li, Yuhang, Skalli, Anas, Berloff, Natalia, Onodera, Tatsuhiro, Oguz, Ilker, Morichetti, Francesco, del Hougne, Philipp, Le Gallo, Manuel, Sebastian, Abu, Mirhoseini, Azalia, Zhang, Cheng, Marković, Danijela, Brunner, Daniel, Moser, Christophe, Gigan, Sylvain, Marquardt, Florian, Ozcan, Aydogan, Grollier, Julie, Liu, Andrea, Psaltis, Demetri, Alù, Andrea, Fleury, Romain   +27 more
openaire   +9 more sources

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Design and validation of the Sport Psychology FAN digital learning application for sports psychology courses

Sriwijaya Journal of Sport
Research Problems: Despite the increasing use of digital learning media in higher education, validated digital applications specifically designed for sports psychology courses remain limited.
Fitri Agung Nanda, Silvi Aryanti, Soleh Solahuddin, Alvin Anggara   +3 more
doaj   +1 more source

Associations between sleep duration, sleep quality, and weight status in Chinese children and adolescents

BMC Public Health, 2022
Background and objective The high prevalence of obesity is a serious problem, and sleep is considered to be a factor for obesity. This study aimed to examine the relationship between sleep duration, sleep quality, and weight status among children and ...
Huan Chen, Li-Juan Wang, Fei Xin, Guo Liang, Yuan Chen   +4 more
doaj   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source