Results 71 to 80 of about 175,402 (298)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Perspectives on the use of aromatherapy from clinicians attending an integrative medicine continuing education event

BMC Complementary and Alternative Medicine, 2019
Background The use of essential oils is growing in the United States, but clinician attitudes, experience, and beliefs regarding their use have not previously been studied.
Amy C. S. Pearson, Susanne M. Cutshall, W. Michael Hooten, Nancy J. Rodgers, Brent A. Bauer, Anjali Bhagra   +5 more
doaj   +1 more source

One Solution for Managing Risks during Cutbacks in Residency Training Programs [PDF]

, 2000
Professors Knott and Ruroede examine the risks associated with downsizing and elimination of physician residency training ...
Knott, Patrick, Ruroede, Kathleen
core   +2 more sources

Dying in long-term care facilities in Europe : the PACE epidemiological study of deceased residents in six countries [PDF]

, 2019
Background: By 2030, 30% of the European population will be aged 60 or over and those aged 80 and above will be the fastest growing cohort. An increasing number of people will die at an advanced age with multiple chronic diseases.
Deliens, Luc, Froggatt, Katherine, Gambassi, Giovanni, Honinx, Elisabeth, Kylänen, Marika, Onwuteaka-Philipsen, Bregje, PACE, on behalf of, Piers, Ruth, Smets, Tinne, Szczerbińska, Katarzyna, Van den Block, Lieve, Van Den Noortgate, Nele, van Dop, Nanja   +12 more
core   +4 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Medical Licensing: An Obstacle to Affordable, Quality Care [PDF]

, 2008
In the United States, the authority to regulate medical professionals lies with the states. To practice within a state, clinicians must obtain a license from that state's government. State statutes dictate standards for licensing and disciplining medical
Shirley Svorny
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Physician Assistants Contribution to Emergency Department Productivity

Western Journal of Emergency Medicine, 2012
Introduction: The objective of this report is to determine physician assistant (PA) productivity in anacademic emergency department (ED) and to determine whether shift length or department censusimpact productivity.Methods: A retrospective chart review ...
Christopher Brook, MD, Alexandra Chomut, MD, Rebecca K. Jeanmonod, MD   +2 more
doaj  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Improving Health Care Efficiency Through the Integration of a Physician Assistant into an Infectious Diseases Consult Service at a Large Urban Community Hospital

Canadian Journal of Infectious Diseases and Medical Microbiology, 2015
BACKGROUND: Physician assistants (PAs) have recently been introduced into the Canadian health care system in some provinces; however, there are little data demonstrating their impact.
Melissa Decloe, Janine McCready, James Downey, Jeff Powis   +3 more
doaj   +1 more source