Results 101 to 110 of about 477,860 (282)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The cost-effectiveness of physician assistants/associates: A systematic review of international evidence

PLoS ONE, 2021
Background The global utilization of the physician assistant/associate (PA) is growing. Their increasing presence is in response to the rising demands of demographic changes, new developments in healthcare, and physician shortages.
G. T. W. J. van den Brink, R. S. Hooker, A. J. Van Vught, H. Vermeulen, M. G. H. Laurant   +4 more
doaj  

Nurse practitioners and physician associates in Swiss healthcare

Physician Associates (PAs) and Nurse Practitioners (NPs) are healthcare professionals with advanced clinical skills who play a key role in strengthening integrated care and mitigating physician shortages.
Zimmermann, Frank, Hermann, Anja, König, Sonja K., Simon, Michael, Perini, Franziska, Capaul-Schmocker, Melanie, Wepf, Markus, Ribaut, Janette, Nienaber, André, Stade, Caroline, Weiss, Judith, Geest, Sabina De, Gisler, Isabelle, Leuppi, Jörg D., Zúñiga, Franziska, Käufeler, Rahel, Manser, Anita, Beckmann, Sonja, Horlacher, Kathrin, Mauthner, Oliver, Gaylord, Jessica, König, Susanne, Leuppi, Jörg, De Geest, Sabina   +23 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Basic Principles of Obstetric Anesthesiology: A Crossword Puzzle [PDF]

Journal of Clinical and Diagnostic Research, 2017
JENNIFER WRIGHT, ALLAN F. SIMPAO, OMAR VISWANATH   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Examining attitudes of referral specialist physicians regarding physician assistant referrals

, 2002
The nature of the relationship between the primary care PA and the specialist physician has not been well studied. It is apparent that although the majority of specialist physicians accept referrals from PAs and are accepting of the role of primary ...
Muma, Richard D., Lary, Marvis J., Enns, Sue M.   +2 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Chronic Eosinophilic Pneumonia as the Initial Manifestation of Rheumatoid Arthritis: A Case Report

Annals of Internal Medicine: Clinical Cases
Chronic eosinophilic pneumonia (CEP) is a rare disorder characterized by peripheral blood eosinophilia, increased eosinophils in bronchoalveolar lavage fluid, and eosinophilic infiltration of lung alveoli and interstitia. While only a handful of cases of
Nuzhat Batool, Jiya Mulayamkuzhiyil, Justeena Joseph, Muhammad Abdul Rehman, Elise Belilos   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source