Results 31 to 40 of about 440,740 (257)

Knowledge and Attitude toward Hospice Palliative Care among Community-Dwelling Aged Taiwanese—Analysis of Related Factors

open access: yesInternational Journal of Gerontology, 2012
Background: This study was conducted to investigate the knowledge and attitude toward hospice palliative care (HPC) among the elderly, defined as 65 years of age and older, living in the metropolitan area of Taiwan.
Ching-Ping Hsu   +3 more
doaj   +1 more source

The pearls and pitfalls of setting high-quality multiple choice questions for clinical medicine

open access: yesSouth African Family Practice, 2023
Multiple choice question (MCQ) examinations have become extremely popular for testing applied knowledge in the basic and clinical sciences. When setting MCQ examinations, assessors need to understand the measures that improve validity and reliability so ...
Mergan Naidoo
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Investment in family medicine to improve health outcomes in sub-Saharan Africa

open access: yesAfrican Journal of Primary Health Care & Family Medicine
Family physicians (FPs), as educators, capacity builders and clinical governance leaders of primary care (PC) teams, work to make them more effective and responsive to the needs of their patients.
Sunanda C. Ray   +4 more
doaj   +1 more source

National Health Insurance – a Bill too far?

open access: yesSouth African Family Practice, 2019
No abstract available.
Bob Mash
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Doctors’ experiences when treating doctor–patients: a scoping review

open access: yesBJGP Open, 2023
Background: To work effectively, doctors need to look after themselves. They often delay seeking medical care for a range of reasons. Once they do, there is evidence that the doctors treating them (’treating doctors’) can struggle to provide optimal ...
Claire J Hutton   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Association Between Sleep Duration and Health Outcome in Elderly Taiwanese

open access: yesInternational Journal of Gerontology, 2011
Background: The aim was to assess the relationship between sleep duration and self-rated health outcome in the elderly Taiwanese. Methods: The data were drawn from the National Survey on Knowledge, Attitude, and Practice of Health Promotion 2002 (HPKAP ...
Meng-Ting Tsou
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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