Results 41 to 50 of about 332,950 (262)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Barriers to Effective Postmenopausal Osteoporosis Treatment: A Qualitative Study of Patients' and Practitioners' Views. [PDF]

PLoS ONE, 2016
Only a minority of patients at high risk for osteoporotic fracture receive treatment.Study patients' and physicians' views regarding postmenopausal osteoporosis (PMO) to identify impediments to good care.A qualitative study involving 18 physicians and 37
Sophie Alami, Lucile Hervouet, Serge Poiraudeau, Karine Briot, Christian Roux   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

(Dis)Incentivizing Patient Satisfaction Metrics: The Unintended Consequences of Institutional Bias

Health Equity, 2019
Background: Patient satisfaction surveys as a metric for quality-based financial incentives carry a risk of bias toward women and underrepresented physicians.
Sylk Sotto-Santiago, James E. Slaven, Theresa Rohr-Kirchgraber   +2 more
doaj   +1 more source

COVID-19 Pandemic and Its Gendered Impact on Indian Physicians

JCO Global Oncology, 2021
PURPOSEThe 2018 WHO health workforce report analyzing gender equity in 104 countries reported that although women constituted 70% of the workers, they were less likely to be employed full-time and faced a 28% gender pay gap. The ongoing COVID-19 pandemic
Sabita Jiwnani, Priya Ranganathan, Virendra Tiwari, Apurva Ashok, Devayani Niyogi, George Karimundackal, C. S. Pramesh   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Presenting Your Best Self: How Physician Appearance Influences Patient Perceptions and Impacts Women in Medicine

Women's Health Reports
Introduction: Trust and rapport between patients and physicians form the cornerstone of effective medical practice. A key factor influencing this trust is the patient’s perception of the physician’s appearance.
Andrea Lopez-Ruiz, Lopa Misra, Lindsey Lamb, Julia Files, Sonal Haerter, Lisa Marks, Neera Agrwal   +6 more
doaj   +1 more source

A pilot study of quality of life in German prehospital emergency care physicians

Journal of Research in Medical Sciences, 2016
Background: Quality of life in patients represents an important area of assessment. However, attention to health professionals should be equally important. The literature on the quality of life (QOL) of emergency physicians is scarce.
Michael Sand, Schapoor Hessam, Falk G Bechara, Daniel Sand, Christian Vorstius, Michael Bromba, Eggert Stockfleth, Ivy Shiue   +7 more
doaj   +1 more source

Emotional intelligence and self-esteem: Personal competencies necessary for physicians

Frontiers in Medicine, 2022
IntroductionEven though emotional intelligence and self-esteem are truly important variables in healthcare, the fact is that there are few studies on these constructs in Spanish physicians.
María del Mar Molero Jurado, María del Carmen Pérez-Fuentes, María del Carmen Pérez-Fuentes, África Martos Martínez, José Jesús Gázquez Linares   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source