Results 51 to 60 of about 167,231 (219)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Patterns and predictors of cholinesterase inhibitor use in dementia with Lewy bodies

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION Current evidence supports the use of cholinesterase inhibitors (ChEIs) as the first‐line symptomatic treatment for improving cognition in dementia with Lewy bodies (DLB).
Rachel J. Heo, Ahmed Negida, Kathryn A. Wyman‐Chick, James R. Bateman, Federico Rodriguez‐Porcel, Brian D. Berman, Nitai Mukhopadhyay, Matthew J. Barrett   +7 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Physician perspectives on the burden and management of asthma in six countries: The Global Asthma Physician Survey (GAPS)

BMC Pulmonary Medicine, 2017
Background Despite recognition of asthma as a growing global issue and development of global guidelines, asthma treatment practices vary between countries. Several studies have reported patients’ perspectives on asthma control.
Kenneth R. Chapman, David Hinds, Peter Piazza, Chantal Raherison, Michael Gibbs, Timm Greulich, Kenneth Gaalswyk, Jiangtao Lin, Mitsuru Adachi, Kourtney J. Davis   +9 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Gender differences in prescribing patterns for patients with Parkinson’s disease in Japan: a retrospective observational study using insurance claims databases

Frontiers in Neurology
BackgroundParkinson’s disease (PD) is a neurodegenerative disorder, with increasing prevalence among aging populations. Gender differences in PD extend to symptom presentation and treatment response, suggesting the need for gender-specific management ...
Morinobu Seki, Morinobu Seki, Yayoi Kawata, Ayako Hayashi, Shinji Fujimoto   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Clinical variability in complementary feeding counseling in Türkiye: results from a pediatrician survey

Frontiers in Pediatrics
IntroductionComplementary feeding (CF) is a critical period in infant nutrition, during which pediatricians play a pivotal role. This study aimed to examine CF recommendations by pediatricians in Türkiye, focusing on differences based on infants’ allergy
Nalan Karabayır, Nalan Karabayır, Demet Deniz Bilgin, Demet Deniz Bilgin, Mine Başıbüyük, Mine Başıbüyük, Övgü Büke, Övgü Büke   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Expert Opinion Report on the Challenges in the Management of Psoriatic Arthritis in United Arab Emirates: A Focus on Interleukin-17 Inhibitors

Open Access Rheumatology: Research and Reviews
Ahmed Abogamal,1 Humeira Badsha,2 Suad Hannawi,3 Ghita Harifi,4 Bhavna Khan,2 Atheer Al Ansari,5 Khalid A Alnaqbi,6,7 Ahmed S Zayat,8 Shady Ibrahim,9 Mohamed Taher,9 Rajaie Namas10 1Rheumatology Department, Al-Azhar University and Zahra Hospital Dubai ...
Abogamal A, Badsha H, Hannawi S, Harifi G, Khan B, Ansari AA, Alnaqbi KA, Zayat AS, Ibrahim S, Taher M, Namas R   +10 more
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