Results 21 to 30 of about 1,135,095 (168)

Institutional animal care and use committees and the challenges of evaluating animal research proposals

Research Integrity and Peer Review
Background In the U.S. and many other countries, animal use in research, testing, and education is under the purview of Institutional Animal Care and Use Committees or similar bodies.
John J. Pippin, Jarrod Bailey, Mark Kennedy, Deborah Dubow Press, Janine McCarthy, Ron Baron, Stephen Farghali, Elizabeth Baker, Neal D. Barnard   +8 more
doaj   +1 more source

Osteoarthritis- a systematic review of long-term safety implications for osteoarthritis of the knee

BMC Musculoskeletal Disorders, 2019
Background There is no cure for knee osteoarthritis (KOA) and typically patients live approximately 30-years with the disease. Most common medical treatments result in short-term palliation of symptoms with little consideration of long-term risk.
Jonathon Charlesworth, Jane Fitzpatrick, Nirmala Kanthi Panagodage Perera, John Orchard   +3 more
doaj   +1 more source

Development of an online public health curriculum for medical students: the public health commute

BMC Medical Education, 2019
Background As public health becomes increasingly central to the practice of medicine, educational efforts are necessary to prepare medical students to apply public health concepts in their care of patients.
Sarah Godfrey, Katherine Nickerson, Jonathan Amiel, Benjamin Lebwohl   +3 more
doaj   +1 more source

Environmental pH modulates inerolysin activity via post-binding blockade

Scientific Reports, 2018
The cholesterol dependent cytolysins (CDCs) are a family of pore-forming toxins produced by a wide range of bacteria. Some CDCs are important virulence factors for their cognate organisms, but their activity must be tightly regulated to ensure they ...
Ryan Rampersaud, Emma L. Lewis, Timothy J. LaRocca, Adam J. Ratner   +3 more
doaj   +1 more source

HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy

EMBO Molecular Medicine, 2023
Iron accumulation causes cell death and disrupts tissue functions, which necessitates chelation therapy to reduce iron overload. However, clinical utilization of deferoxamine (DFO), an iron chelator, has been documented to give rise to systemic adverse ...
Yang Kong, Pei‐Kang Liu, Yao Li, Nicholas D Nolan, Peter M J Quinn, Chun‐Wei Hsu, Laura A Jenny, Jin Zhao, Xuan Cui, Ya‐Ju Chang, Katherine J Wert, Janet R Sparrow, Nan‐Kai Wang, Stephen H Tsang   +13 more
doaj   +1 more source

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

Emerging Microbes and Infections, 2022
The repeated emergence of highly pathogenic human coronaviruses as well as their evolving variants highlight the need to develop potent and broad-spectrum antiviral therapeutics and vaccines.
Pengfei Wang, Ryan G. Casner, Manoj S. Nair, Jian Yu, Yicheng Guo, Maple Wang, Jasper F.-W. Chan, Gabriele Cerutti, Sho Iketani, Lihong Liu, Zizhang Sheng, Zhiwei Chen, Kwok-Yung Yuen, Peter D. Kwong, Yaoxing Huang, Lawrence Shapiro, David D. Ho   +16 more
doaj   +1 more source

Ventromedial prefrontal cortex/anterior cingulate cortex Glx, glutamate, and GABA levels in medication-free major depressive disorder

Translational Psychiatry, 2021
Glutamate (Glu) and gamma-aminobutyric acid (GABA) are implicated in the pathophysiology of major depressive disorder (MDD). GABA levels or GABAergic interneuron numbers are generally low in MDD, potentially disinhibiting Glu release.
Joshua T. Kantrowitz, Zhengchao Dong, Matthew S. Milak, Rain Rashid, Lawrence S. Kegeles, Daniel C. Javitt, Jeffrey A. Lieberman, J. John Mann   +7 more
doaj   +1 more source

Posmetnaya TV. Peculiarities of clinical and X-ray findings at women during postmenopause with chronic generalized periodontitis determined by mineral bone density [PDF]

Саратовский научно-медицинский журнал, 2016
The aim: to study clinical and X-ray specifics of chronic generalized periodontitis of women during a postmenopaus-al period determined by mineral bone density. Material and Methods.
Eremina N.V., Ismailova О.А., Strukov V.I., Kirillova T.V.   +3 more
doaj  

The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury

Nature Communications, 2022
Acute lung injury caused by inhalation of pathogens leads to mortality, but the mechanisms are unclear. Here, the authors show in mice that that loss of the mitochondrial calcium uniporter (MCU) of alveolar type 2 cells (AT2) impaired mitochondrial Ca2 ...
Mohammad Naimul Islam, Galina A. Gusarova, Shonit R. Das, Li Li, Eiji Monma, Murari Anjaneyulu, Liberty Mthunzi, Sadiqa K. Quadri, Edward Owusu-Ansah, Sunita Bhattacharya, Jahar Bhattacharya   +10 more
doaj   +1 more source

Cultural Humility with Lesbian, Gay, Bisexual, and Transgender Populations: A Novel Curriculum in LGBT Health for Clinical Medical Students

MedEdPORTAL, 2013
Lesbian, gay, bisexual, and transgender (LGBT) individuals encounter documented health disparities in the United States, perpetuated in part by limited LGBT-related content in medical education curricula.
Hilary Grubb, Hilda Hutcherson, Jonathan Amiel, Jane Bogart, Justin Laird   +4 more
doaj   +1 more source