Results 51 to 60 of about 2,165,213 (344)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Comparative Accuracy of Diagnosis by Collective Intelligence of Multiple Physicians vs Individual Physicians

JAMA Network Open, 2019
This cross-sectional study uses cases from the Human Diagnosis Project to compare the accuracy of single-physicians’ diagnoses with pooled diagnoses from groups of physicians.
Michael Lawrence Barnett, Dhruv Boddupalli, S. Nundy, D. Bates   +3 more
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury

Nature Communications, 2022
Acute lung injury caused by inhalation of pathogens leads to mortality, but the mechanisms are unclear. Here, the authors show in mice that that loss of the mitochondrial calcium uniporter (MCU) of alveolar type 2 cells (AT2) impaired mitochondrial Ca2 ...
Mohammad Naimul Islam, Galina A. Gusarova, Shonit R. Das, Li Li, Eiji Monma, Murari Anjaneyulu, Liberty Mthunzi, Sadiqa K. Quadri, Edward Owusu-Ansah, Sunita Bhattacharya, Jahar Bhattacharya   +10 more
doaj   +1 more source

The effect of race and sex on physicians' recommendations for cardiac catheterization.

New England Journal of Medicine, 1999
BACKGROUND Epidemiologic studies have reported differences in the use of cardiovascular procedures according to the race and sex of the patient. Whether the differences stem from differences in the recommendations of physicians remains uncertain ...
K. Schulman, J. Berlin, W. Harless, J. Kerner, Shyrl Sistrunk, B. Gersh, Ross Dube, Christopher K. Taleghani, J. E. Burke, Sankey V. Williams, J. Eisenberg, J. Escarce   +11 more
semanticscholar   +1 more source

THE PHYSICIAN IN HAWAII. [PDF]

Journal of the American Medical Association, 1900
As disease and death have prevailed among all people, from the earliest period, so physicians have always been a necessary evil. Since the day Adam got rheumatism cooling off too quickly after his day's work, and Eve became subject to nervous headaches, worrying over the meals and the children, the doctors have been with us, and, unless they meet with ...
openaire   +4 more sources

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Cultural Humility with Lesbian, Gay, Bisexual, and Transgender Populations: A Novel Curriculum in LGBT Health for Clinical Medical Students

MedEdPORTAL, 2013
Lesbian, gay, bisexual, and transgender (LGBT) individuals encounter documented health disparities in the United States, perpetuated in part by limited LGBT-related content in medical education curricula.
Hilary Grubb, Hilda Hutcherson, Jonathan Amiel, Jane Bogart, Justin Laird   +4 more
doaj   +1 more source

Debate about compulsory cremation of victims of COVID-19

Journal of the College of Community Physicians, 2020
No abstract ...
. College of Community Physicians of Sri Lanka
doaj   +1 more source

Interactions between physicians and the pharmaceutical industry generally and sales representatives specifically and their association with physicians’ attitudes and prescribing habits: a systematic review

BMJ Open, 2017
Objectives The objective of this review is to explore interactions between physicians and the pharmaceutical industry including sales representatives and their impact on physicians’ attitude and prescribing habits.
Freek Fickweiler, W. Fickweiler, Ewout Urbach   +2 more
semanticscholar   +1 more source