Results 51 to 60 of about 29,946 (302)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

PDE-NetGen 1.0: from symbolic partial differential equation (PDE) representations of physical processes to trainable neural network representations [PDF]

Geoscientific Model Development, 2020
Bridging physics and deep learning is a topical challenge. While deep learning frameworks open avenues in physical science, the design of physically consistent deep neural network architectures is an open issue.
O. Pannekoucke, R. Fablet
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Conformalized Physics-Informed Neural Networks

CoRR
Physics-informed neural networks (PINNs) are an influential method of solving differential equations and estimating their parameters given data. However, since they make use of neural networks, they provide only a point estimate of differential equation parameters, as well as the solution at any given point, without any measure of uncertainty. Ensemble
Lena Podina, Mahdi Torabi Rad, Mohammad Kohandel   +2 more
openaire   +2 more sources

Solution of Schrödinger Equation for Quantum Systems via Physics-Informed Neural Networks [PDF]

, 2023
openThe numerous successes achieved by machine learning techniques in many technical areas have sparked interest in the scientific community for their application in science.
ZINESI, PAOLO
core  

Training Physics- Informed Neural Networks via Multi-Task Optimization for Traffic Density Prediction

, 2023
Physics-informed neural networks (PINN s) are a newly emerging research frontier in machine learning, which incorporate certain physical laws that govern a given data set, e.g., those described by partial differential equations (PDEs), into the training ...
Dia, H, Grzybowska, H, Wang, B, Shafiei, S, Qin, AK, Mihaita, A-S   +5 more
core   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

SPIKANs: separable physics-informed Kolmogorov–Arnold networks

Machine Learning: Science and Technology
Physics-Informed Neural Networks (PINNs) have emerged as a promising method for solving partial differential equations (PDEs) in scientific computing.
Bruno Jacob, Amanda A Howard, Panos Stinis   +2 more
doaj   +1 more source

Online Continual Physics-Informed Learning for Quadrotor State Estimation Under Wind-Induced Disturbances

Aerospace
Accurate state estimation for quadrotors under wind-induced disturbances remains a critical challenge in dynamic outdoor environments. Existing model-based and data-driven approaches often struggle with real-time adaptation and catastrophic forgetting ...
Yanhui Liu, Shuopeng Wang, Junhua Shi, Lina Hao   +3 more
doaj   +1 more source

Quasi-random physics-informed neural networks

Neurocomputing
Physics-informed neural networks have shown promise in solving partial differential equations (PDEs) by integrating physical constraints into neural network training, but their performance is sensitive to the sampling of points. Based on the impressive performance of quasi Monte-Carlo methods in high dimensional problems, this paper proposes Quasi ...
Tianchi Yu, Ivan V. Oseledets
openaire   +2 more sources