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Biological evolution and statistical physics [PDF]

Advances in Physics, 2001
This review is an introduction to theoretical models and mathematical calculations for biological evolution, aimed at physicists. The methods in the field are naturally very similar to those used in statistical physics, although the majority of publications appeared in biology journals. The review has three parts, which can be read independently.
openaire   +2 more sources

Agency, qualia and life: connecting mind and body biologically [PDF]

, 2017
Many believe that a suitably programmed computer could act for its own goals and experience feelings. I challenge this view and argue that agency, mental causation and qualia are all founded in the unique, homeostatic nature of living matter.
A Damasio, A Pross, AM Turing, B Russell, C Gallistel, CS Carver, CS Carver, DM MacKay, E Nagasako, ED Schneider, G Mather, H Jonas, H Oshima, I Prigogine, J Gribbin, J Kim, J Kim, J Sachs, J Winston, JM Simmons, K Richter, M Born, M Kinoshita, M Raichle, N Block, N Yanofsky, P Johnson-Laird, P Machamer, P Shizgal, R Marken, RG Heath, S Bensmaia, WT Powers, X Barandarian   +33 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Mass Extinctions vs. Uniformitarianism in Biological Evolution

, 1995
It is usually believed that Darwin's theory leads to a smooth gradual evolution, so that mass extinctions must be caused by external shocks. However, it has recently been argued that mass extinctions arise from the intrinsic dynamics of Darwinian ...
Bak, Per, Paczuski, Maya
core   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Biological physically unclonable function [PDF]

Communications Physics, 2019
AbstractInformation security is one of the foundational requirements for any modern society thriving on digital connectivity. At present, information security is accomplished either through software algorithms or hardware protocols. Software algorithms use pseudo random numbers generated by one-way mathematical functions that are computationally robust
Akshay Wali, Akhil Dodda, Yang Wu, Andrew Pannone, Likhith Kumar Reddy Usthili, Sahin Kaya Ozdemir, Ibrahim Tarik Ozbolat, Saptarshi Das   +7 more
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Investigating Biological Matter with Theoretical Nuclear Physics Methods

, 2011
The internal dynamics of strongly interacting systems and that of biomolecules such as proteins display several important analogies, despite the huge difference in their characteristic energy and length scales.
a Beccara S, Coffey W T, Faccioli P, Finkelstein A V, Leach A R, Negele J W, Pietro Faccioli, Schwabl F   +7 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source