Results 81 to 90 of about 692,439 (328)

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Understanding Contributors of Resilience in Youth With Childhood‐Onset Systemic Lupus Erythematosus Through a Socioecological Lens: A Mixed‐Methods Study

Arthritis Care &Research, EarlyView.
Objective This study aimed to identify themes contributing to resilience in childhood‐onset systemic lupus erythematosus (cSLE), distinguish between profiles of resilience, and examine how they relate to underlying themes and patient characteristics. Methods We conducted a mixed‐methods study of 21 patients with cSLE aged 11 to 19 years at a Canadian ...
Isabella Zaffino, Louise Boulard, Joanna Law, Asha Jeyanathan, Lawrence Ng, Sandra Williams‐Reid, Kiah Reid, Angela Cortes, Eugene Cortes, Ashley Danguecan, Deborah M. Levy, Linda T. Hiraki, Andrea M. Knight   +12 more
wiley   +1 more source

String Theory: A Framework for Quantum Gravity and Various Applications [PDF]

, 2008
In this semi-technical review we discuss string theory (and all that goes by that name) as a framework for a quantum theory of gravity. This is a new paradigm in theoretical physics that goes beyond relativistic quantum field theory.
Wadia, Spenta R.
core   +1 more source

Hard Sphere Dynamics for Normal and Granular Fluids

, 2005
A fluid of N smooth, hard spheres is considered as a model for normal (elastic collisions) and granular (inelastic collisions) fluids. The potential energy is discontinuous for hard spheres so the pairwise forces are singular and the usual forms of ...
APARNA BASKARAN, Beijeren, Brey, Domaradzki, Dufty, Dufty, Dufty, Ernst, JAMES W. DUFTY, Lutsko, Lutsko, Sengers   +11 more
core   +1 more source

Association of Elevated Serum S100A8/A9 Levels and Cognitive Impairment in Patients With Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective Cognitive impairment (CI) is common in patients with systemic lupus erythematosus (SLE). Despite its prevalence, the immune mechanisms are not well understood. We previously reported elevated serum levels of S100A8/A9 and matrix metalloproteinase 9 (MMP‐9) in patients with SLE and CI.
Carolina Muñoz‐Grajales, Michelle L. Barraclough, Juan P. Diaz‐Martinez, Jiandong Su, Kathleen Bingham, Mahta Kakvan, Roberta Pozzi Kretzmann, Maria Carmela Tartaglia, Lesley Ruttan, May Y. Choi, Simone Appenzeller, Sherief Marzouk, Dennisse Bonilla, Patricia Katz, Dorcas Beaton, Robin Green, Dafna D. Gladman, Joan Wither, Zahi Touma   +18 more
wiley   +1 more source

CELSS science needs [PDF]

Questions and areas of study that need to be persued in order to develope a Controlled Ecological Life Support System are posed. Research topics needing attention are grouped under various leadings: ecology, genetics, plant pathology, cybernetics ...
Rummel, J. D.
core   +1 more source

Averaged dynamics of two-phase media in a vibration field

, 2006
The averaged dynamics of various two-phase systems in a high-frequency vibration field is studied theoretically. The continuum approach is applied to describe such systems as solid particle suspensions, emulsions, bubbly fluids, when the volume ...
Lyubimov, Dmitry V., Shklyaev, Sergey V., Straube, Arthur V.   +2 more
core   +1 more source

What does computational fluid dynamics tell us about intracranial aneurysms? A meta-analysis and critical review

Journal of Cerebral Blood Flow and Metabolism, 2019
Despite the plethora of published studies on intracranial aneurysms (IAs) hemodynamic using computational fluid dynamics (CFD), limited progress has been made towards understanding the complex physics and biology underlying IA pathophysiology.
Khalid M. Saqr, Sherif Rashad, S. Tupin, Kuniyasu Niizuma, T. Hassan, T. Tominaga, M. Ohta   +6 more
semanticscholar   +1 more source

Development of a personalized visualization and analysis tool to improve clinical care in complex multisystem diseases with application to scleroderma

Arthritis Care &Research, Accepted Article.
Background In complex diseases, it is challenging to assess a patient's disease state, trajectory, treatment exposures, and risk of multiple outcomes simultaneously, efficiently and at the point of care. Methods We developed an interactive patient‐level data visualization and analysis tool (VAT) that automates illustration of a scleroderma patient's ...
Ji Soo Kim, John Scott, Lauren Fisher, Lauren N. Smith, Willie Stewart, Adrianne Woods, Rob Smithwright, Diane Koher, Parastoo Aslanbeik, Aalok B. Shah, Brad Tibbils, Samantha I. Pitts, Ayse P. Gurses, Yushi Yang, Ana‐Maria Orbai, Antony Rosen, Laura K. Hummers, Scott L. Zeger, Ami A. Shah   +18 more
wiley   +1 more source

Identification of vortexes obstructing the dynamo mechanism in laboratory experiments

, 2013
The magnetohydrodynamic dynamo effect explains the generation of self-sustained magnetic fields in electrically conducting flows, especially in geo- and astrophysical environments.
Forest, Cary B, Hatch, David R, Jenko, Frank, Limone, Angelo   +3 more
core   +1 more source