Results 31 to 40 of about 2,394,637 (257)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Journeys from quantum optics to quantum technology [PDF]

, 2017
Sir Peter Knight is a pioneer in quantum optics which has now grown to an important branch of modern physics to study the foundations and applications of quantum physics. He is leading an effort to develop new technologies from quantum mechanics. In this
Phoenix, S., Jiannis K. Pachos, Murao, M, Emmanuel Paspalakis (5420219), Milburn, GJ, Ekert, A, Paspalakis, E., Beige, Almut, Beige, A., Piraux, B., Jason Twamley, Stephen M Barnett (16071104), Milburn, Gerard J., Pachos, JK, Palma, G. Massimo, Murao, Mio, Twamley, Jason, Barry M. Garraway, Martin B. Plenio, Vidiella-Barranco, A., Christoph H. Keitel, Almut Beige (14345382), Artur Ekert, Phoenix, Simon J. D., Kim, M.S., Christoph H Keitel (16245221), Benard Piraux (16245239), Viv Kendon, Kim, M. S., Simon J D Phoenix (16245236), Plenio, Martin B., Palma, G., Twamley, J, Phoenix, Simon J.D., Garraway, Barry M., Vidiella Barranco, A., Manfred Lein (3987074), M.S. Kim, Almut Beige, Gerard J Milburn (16078628), Pachos, J., Keitel, Christoph H., Milburn, G., Palma, GM, Jiannis K Pachos (16245233), Benard Piraux, Piraux, Benard, Phoenix, SJD, Moya-Cessa, Héctor M., Ekert, A., Viv Kendon (16245224), Manfred Lein, Barnett, Stephen M., Lein, M., G. Massimo Palma, Kim, M., PALMA, Gioacchino Massimo, Moya-Cessa, HM, Martin B Plenio (16245242), Barry C. Sanders, Vidiella-Barranco, A, A Vidiella-Barranco (16245248), Sanders, Barry C., Piraux, B, Moya-Cessa, H., Barry C Sanders (16245245), Lein, M, Kendon, V, Lein, Manfred, Kendon, Viv, Murano, Mio, Ekert, Artur, Paspalakis, Emmanuel, Plenio, MB, Pachos, Jiannis K., Stephen M. Barnett, Gerard J. Milburn, Garraway, BM, Héctor M Moya-Cessa (16245227), Plenio, M., Mio Murao (16245230), Paspalakis, E, Keitel, C., Barnett, S., Kendon, V., A. Vidiella-Barranco, Jason Twamley (14387343), Beige, A, Artur Ekert (16245218), G. Massimo Palma (14407791), Moya Cessa, H., Simon J.D. Phoenix, M S Kim (13632556), Sanders, BC, Emmanuel Paspalakis, Piraux, Bernard, Murao, M., Barry M. Garraway (4461409), Keitel, CH, Mio Murao, Héctor M. Moya-Cessa, Barnett, SM, Kim, MS, Garraway, B., Twamley, J., Sanders, B., Pachos JK, Phoenix SJD, Garraway BM, Kendon V, Paspalakis E, Garraway, B. M., Pachos, J. K., Kim MS, Palma GM, Beige A, Phoenix, S. J. D., Barnett SM, Lein M, Barnett, S. M., MoyaCessa HM, Keitel CH, Palma, G. M., Moya-Cessa, H. M., Sanders BC, Milburn, G. J., Keitel, C. H., Ekert A, VidiellaBarranco A, Plenio, M. B., Plenio MB, Milburn GJ, Murao M, Twamley J, Piraux B, Sanders, B. C.   +135 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

International Conference on Laser Physics and Quantum Optics

, 2000
Since the advent of the laser about 40 years ago, the field of laser physics and quantum optics have evolved into a major discipline. The early studies included the optical coherence theory and the semiclassical and quantum mechanical theories of the ...
Zhu, Shi-Yao, Scully, Marlan, Xu, Zhizhan, Xie, Shengwu   +3 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Fundamentals of physics II: electromagnetism, optics, and quantum mechanics

, 2020
A beloved introductory physics textbook, now including exercises and an answer key, accessibly explains electromagnetism, optics, and quantum ...
Shankar, R
core  

Experimental sets in optics for Interactive Physics Laboratory [PDF]

, 2017
Title: Experimental sets in optics for Interactive Physics Laboratory Author: Jana Machalická Department: Department of Physics Education Supervisor: RNDr.
Machalická, Jana
core  

Physics-informed Neural Network for Nonlinear Dynamics in Fiber Optics

, 2021
A physics-informed neural network (PINN) that combines deep learning with physics is studied to solve the nonlinear Schr\"odinger equation for learning nonlinear dynamics in fiber optics.
Alan Pak Tao Lau (5683478), Chao Lu (4374), Xiaotian Jiang (8595033), Danshi Wang (5061215), Min Zhang (111999), Qirui Fan (14406807)   +5 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source