Results 41 to 50 of about 3,101,300 (229)

Development of quantum perspectives in modern physics [PDF]

, 2009
Introductory undergraduate courses in classical physics stress a perspective that can be characterized as realist; from this perspective, all physical properties of a classical system can be simultaneously specified and thus determined at all future ...
Charles Baily, Baily, Charles, Finkelstein, Noah D., Noah D. Finkelstein   +3 more
core   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

An exact collisionless equilibrium for the Force-Free Harris Sheet with low plasma beta [PDF]

, 2015
Funding: STFC Consolidated Grant [ST/K000950/1] (OA, TN & FW) and a Doctoral Training Grant [ST/K502327/1] (OA). EPSRC Doctoral Training Grant [EP/K503162/1] (ST).We present a first discussion and analysis of the physical properties of a new exact ...
Allanson, Oliver, Allanson, O.; id_orcid, Troscheit, Sascha, S. Troscheit, Wilson, F., Neukirch, T., Wilson, Fiona, Troscheit, S., O. Allanson, F. Wilson, Neukirch, Thomas, T. Neukirch, Allanson, Oliver Douglas   +12 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Designing a tokamak fusion reactor—How does plasma physics fit in?

, 2015
This paper attempts to bridge the gap between tokamak reactor design and plasma physics. The analysis demonstrates that the overall design of a tokamak fusion reactor is determined almost entirely by the constraints imposed by nuclear physics and fusion ...
Mangiarotti, Franco Julio, Minervini, Joseph V, Freidberg, Jeffrey P.   +2 more
core   +1 more source

Magnetotail dipolarization and associated current systems observed by Cluster and Double Star [PDF]

, 2008
A dipolarization and its associated current systems are studied using Cluster, Double Star TC1, and ground-based observations. The Cluster spacecraft are located approximately 16 RE downtail near 0030 LT.
Cao, X., A. T. Y. Lui (7591487), X. Cao (2942316), Z. Pu (5722523), C. M. Carr (7592234), Grocott A, Shen C, Kistler, L., Lun, X., Alexeev, I., Lui, A. T. Y., Lui ATY, Mouikis C, Vörös Z, T. L. Zhang (7591511), Fazakerley, A. N., Dunlop, M., Baumjohann W, Shen, C., M. G. G. T. Taylor (7592117), A. Runov (7592228), Runov A, Dunlop, M. W., Klecker B, Zhang, T., Rème, H., Volwerk, M., W. Baumjohann (7592225), Pu, Z., Nakamura, R., Lester, M., Lester M, Z. Vörös (7592231), Runov, A., Grocott, A., Takada T, M. Lester (7589660), A. N. Fazakerley (7591259), C. Shen (1630555), Lun X, B. Klecker (7591355), Alexeev I, Pu Z, Zhang TL, Taylor, M. G. G. T., Zhang, T. L., Nakamura R, Taylor MGGT, Lui, A., J. K. Shi (7591508), Fazakerley, A., Vörös, Z., Shi JK, Klecker, B., M. Volwerk (7591490), Walsh AP, Carr CM, Adrian Grocott (7590026), T. Takada (7591877), Shi, J., Voeroes, Z., Walsh, A., L. M. Kistler (7591505), C. Mouikis (7591502), Takada, T., I. V. Alexeev (7591496), M. W. Dunlop (7591493), Taylor, M., Carr, C. M., Dunlop MW, Baumjohann, W., H. Rème (7591274), Mouikis, C., Kistler L, R. Nakamura (7591343), Volwerk M, Rème H, Carr, C., Cao X, Walsh, A. P., Shi, J. K., A. P. Walsh (7591499), Fazakerley AN, X. Lun (7592222)   +83 more
core   +1 more source

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons, Nuria Guillen, Jordi Sarto, Neus Falgàs, Sergi Borrego‐Écija, Diana Esteller‐Gauxax, Magda Castellví, Adrià Tort‐Merino, Agnès Pérez‐Millan, Anna Antonell, Josep M. Augè Fradera, Gerard Piñol, Iolanda Riba, Anna Carnes‐Vendrell, Marta Cullell, Maria Teresa Osuna, Lorena Bajo, Teresa Romero, Eva Bonjoch, Joan Bello, Susana Fernández, Marta Balagué, Isabel Gómez‐Ruiz, Anuncia Boltes, Claustre Pont, Raquel Cuevas, Sara Carrillo, Laura Iglesias, Teresa Maria Casadevall Codina, Lorena Grau Guinea, Fernando Jose Espada, Raquel Sánchez‐Valle, Mircea Balasa, Albert Lladó   +33 more
wiley   +1 more source