Results 101 to 110 of about 936,632 (291)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Hidden Higgs portal vector dark matter for the Galactic center gamma-ray excess from the two-step cascade annihilation, and muon g − 2

open access: yesJournal of High Energy Physics, 2018
We have built a lepton-specific next-to-minimal two-Higgs-doublet-portal vector dark matter model. The vector dark matter in the hidden sector does not directly couple to the visible sector, but instead annihilates into the hidden Higgs bosons which ...
Kwei-Chou Yang
doaj   +1 more source

Physics Beyond the Standard Model at LHeC

open access: yes15th International Workshop on Deep-Inelastic Scattering and Related Subjects DIS 2007, 2007
Proceedings of DIS 2007, p.1133-1136, ISBN 978-3-935702-23-2, ISSN 1435 ...
openaire   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

SuperGZK neutrinos: testing physics beyond the Standard Model

open access: yes, 2003
The sources and fluxes of superGZK neutrinos, $E>10^{20}$ eV, are discussed. The most promising sources are reionization bright phase, topological defects, superheavy dark matter and mirror matter.
Berezinsky, Veniamin
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Explanation of IceCube spectrum with ν → 3ν neutrino splitting in a ν2HDM model

open access: yesJournal of High Energy Physics, 2018
A single power law flux spectrum of high energy neutrinos does not adequately explain the entire 60 TeV to 10 PeV event spectrum observed at IceCube, specially the excess of PeV events and the lack of Glashow resonance events expected at 6.3 PeV cannot ...
Subhendra Mohanty, Soumya Sadhukhan
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

Home - About - Disclaimer - Privacy