Results 71 to 80 of about 936,632 (291)
Beyond the Standard Model of Physics with Astronomical Observations
, 2013 There has been significant recent progress in observational cosmology. This, in turn, has provided an unprecedented picture of the early universe and its evolution.
Jimenez, Raul
core +1 more source
Neutrinos and physics beyond the standard model [PDF]
Nuclear Physics B - Proceedings Supplements, 1997 A brief sketch is made of the present observational status of neutrino physics, with emphasis on the hints that follow from solar and atmospheric neutrino observations, as well as cosmological data on the amplitude of primordial density fluctuations. I also briefly review the ways to account for the observed anomalies and some of their implications.
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
BEACH 2014 Theory summary [PDF]
, 2014 I summarize key aspects of the quest for physics beyond the Standard Model in flavour physics as discussed at the BEACH 2014 conference in ...
Jaeger, Sebastian
core +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Scalar dark matter: real vs complex
Journal of High Energy Physics, 2017 We update the parameter spaces for both a real and complex scalar dark matter via the Higgs portal. In the light of constraints arising from the LUX 2016 data, the latest Higgs invisible decay and the gamma ray spectrum, the dark matter resonant mass ...
Hongyan Wu, Sibo Zheng
doaj +1 more source
Journal of High Energy Physics, 2020 We perform a comprehensive analysis for the light scalar dark matter (DM) in the Inert two Higgs doublet model (i2HDM) with compressed mass spectra, small mass splittings among three ℤ2 odd particles — scalar S, pseudo-scalar A, and charged Higgs H ...
Yue-Lin Sming Tsai +2 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source