Results 31 to 40 of about 6,454,505 (250)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Nonlinear interaction in composites using physics informed neural networks [PDF]
Modelling of composites requires the consideration of various components that work together and interact in a linear and nonlinear way. Linear and nonlinear modelling in view of demanding needs, like representative volume element calculations within ...
Drosopoulos, Georgios +2 more
core +3 more sources
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Physics-Informed Neural Networks for Microprocessor Thermal Management Model
IEEE Access, 2023 The cooling of microprocessors has emerged as a crucial challenge in enhancing performance. Various studies are being conducted to optimize the structural design for microprocessor cooling.
Hwijae Son, Hyunwoo Cho, Hyung Ju Hwang
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Physics Informed Neural Networks for Engineering Systems
, 2020 This thesis explores the application of deep learning techniques to problems in fluid mechanics, with particular focus on physics informed neural networks.
Sukirt, None
core +1 more source
SPIKANs: separable physics-informed Kolmogorov–Arnold networks
Machine Learning: Science and TechnologyPhysics-Informed Neural Networks (PINNs) have emerged as a promising method for solving partial differential equations (PDEs) in scientific computing.
Bruno Jacob +2 more
doaj +1 more source
AerospaceAccurate state estimation for quadrotors under wind-induced disturbances remains a critical challenge in dynamic outdoor environments. Existing model-based and data-driven approaches often struggle with real-time adaptation and catastrophic forgetting ...
Yanhui Liu +3 more
doaj +1 more source