Sex-Specific Physiological Responses to Ultramarathon
, 2022 Nicholas B. Tiller +11 more
openalex +2 more sources
Potential drug-drug interaction of olverembatinib (HQP1351) using physiologically based pharmacokinetic models [PDF]
, 2022 Zhiheng Yu +10 more
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Gut cannabinoid receptor 1 regulates alcohol binge-induced intestinal permeability
eGastroenterologyBackground Endocannabinoids acting via cannabinoid receptor 1 (CB1R) can elicit increased intestinal permeability (a condition also called ‘leaky gut’).
Bin Gao +6 more
doaj +1 more source
Physiological and Metabolic Responses of Freshwater and Brackish-Water Strains of Microcystis aeruginosa Acclimated to a Salinity Gradient: Insight into Salt Tolerance [PDF]
, 2019 Maxime Georges des Aulnois +8 more
openalex +1 more source
Genome editing in non-model organisms opens new horizons for comparative physiology [PDF]
, 2020 Michael H. Dickinson +2 more
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Quantitative Risk Analysis for N-Methyl Pyrrolidone Using Physiologically Based Pharmacokinetic and Benchmark Dose Modeling [PDF]
, 2009 Torka S. Poet +5 more
openalex +1 more source
Environmental heterogeneity shapes physiological traits in tropical direct‐developing frogs
, 2021 Ruth Percino‐Daniel +5 more
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source