Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson+12 more
wiley +1 more source
Development of a personalized digital biomarker of vaccine-associated reactogenicity using wearable sensors and digital twin technology. [PDF]
Steinhubl SR+10 more
europepmc +1 more source
Co-integrating thermal and hemodynamic imaging for physiological monitoring
Mackenzie Wilson+3 more
openalex +2 more sources
This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput+5 more
wiley +1 more source
A deep learning model integrating domain-specific features for enhanced glaucoma diagnosis. [PDF]
Xu J, Jing E, Chai Y.
europepmc +1 more source
This study presents a novel method using laser‐induced graphene (LIG) to enable high‐yield transfer of silver nanowire (AgNW) networks onto ultra‐low modulus, breathable silicone substrates. This approach creates ultra‐conformal epidermal electrodes (≈50 µm) for long‐term, high‐fidelity electrophysiological monitoring, even in challenging conditions ...
Jiuqiang Li+10 more
wiley +1 more source
Impact of Temporal Resolution on Autocorrelative Features of Cerebral Physiology from Invasive and Non-Invasive Sensors in Acute Traumatic Neural Injury: Insights from the CAHR-TBI Cohort. [PDF]
Vakitbilir N+11 more
europepmc +1 more source
A Vertically‐Stacked Optoelectronic Sensor for Localized Hemodynamics Monitoring
This work introduces a hemodynamics monitoring sensor that features vertically stacked microLEDs and a heterogeneously integrated photodetector. The vertically stacked microLEDs enable localized measurements, and by designing the interoptode distance according to the depth of the target region, this vertically stacked optoelectronic sensor is ...
Taeyeon Lee+9 more
wiley +1 more source
Translating biomarker insights into practice: a path forward in TA-TMA management. [PDF]
Jodele S, Gavriilaki E.
europepmc +1 more source
How consumer physical activity monitors could transform human physiology research
Stephen P. Wright+3 more
openalex +2 more sources