Results 61 to 70 of about 163,535 (275)

Using lactate threshold to predict 5-km treadmill running performance in veteran athletes

Biology of Sport, 2017
Measuring lactate threshold to predict endurance performance is difficult among veteran athletes, due to age-related decreases in net lactate concentration.
Jacky Forsyth, Dean Burt, Fiona Ridley, Christopher Mann   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Case report: dynamic personalized physiological monitoring in lung cancer using wearable data

Frontiers in Oncology
Pretreatment prognostication, on-treatment monitoring, and early detection of physiological symptoms are considerable challenges in cancer. We describe the feasibility of high-resolution wearable data (steps per day, walking speed) to longitudinally ...
Joshua W. Bliss, Whitney P. Underwood, Adele M. Carlson, Jessica M. Scott, Jessica M. Scott, Robert Daly, Robert Daly, Bob T. Li, Bob T. Li, Alexander Drilon, Alexander Drilon, Peter Stetson, Peter Stetson, Paul C. Boutros, Paul C. Boutros, Paul C. Boutros, Paul C. Boutros, Lee W. Jones, Lee W. Jones   +18 more
doaj   +1 more source

Drug-Related Hospital Visits and Admissions Associated with Laboratory or Physiologic Abnormalities-A Systematic-Review.

PLoS ONE, 2013
Countless studies have demonstrated that many emergency-room visits and hospital admissions are drug-related and that a significant proportion of these drug-related visits (DRVs) are preventable.
Kerry Wilbur, Huda Hazi, Aya El-Bedawi
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Perfluorooctane Sulfonate (PFOS) and Related Perfluorinated Compounds in Human Maternal and Cord Blood Samples: Assessment of PFOS Exposure in a Susceptible Population during Pregnancy [PDF]

, 2004
Fluorinated organic compounds (FOCs), such as perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorooctane sulfonylamide (PFOSA), are widely used in the manufacture of plastic, electronics, textile, and construction material in the ...
Akiko Uno, Calafat AM, Fumihiro Sata, Fumio Okada, Hiroyuki Nakazawa, Koichi Inoue, Reiko Kishi, Rie Ito, Seiko Sasaki, Shizue Kato, Sonomi Nakajima, U.S. EPA, Yasuaki Saijo, Yoshihiro Yoshimura   +13 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The impact of high grade glial neoplasms on human cortical electrophysiology [PDF]

, 2017
ObjectiveThe brain's functional architecture of interconnected network-related oscillatory patterns in discrete cortical regions has been well established with functional magnetic resonance imaging (fMRI) studies or direct cortical electrophysiology from
Bandt, S. Kathleen, Breshears, Jonathan D, Bundy, David T, Hacker, Carl D, Leuthardt, Eric C, Pahwa, Mrinal, Roland, Jarod L, Sharma, Mohit, Shimony, Joshua S   +8 more
core   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Statistical properties of cerebral near infrared and intracranial pressure-based cerebrovascular reactivity metrics in moderate and severe neural injury: a machine learning and time-series analysis

Intensive Care Medicine Experimental, 2023
Background Cerebrovascular reactivity has been identified as a key contributor to secondary injury following traumatic brain injury (TBI). Prevalent intracranial pressure (ICP) based indices of cerebrovascular reactivity are limited by their invasive ...
Alwyn Gomez, Amanjyot Singh Sainbhi, Kevin Y. Stein, Nuray Vakitbilir, Logan Froese, Frederick A. Zeiler   +5 more
doaj   +1 more source