Results 291 to 300 of about 1,880,647 (379)

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

Integrated transcriptomics and physio-biochemical analysis revealed key genes affecting the seed germination of <i>Leymus chinensis</i>. [PDF]

Front Plant Sci
Feng Y, Gong W, Liu L, Tian C, Yang Y, Wu Z.   +5 more
europepmc   +1 more source

Genome‐Wide Association Analyses Reveal the Genetic Basis of EMS Mutagenesis Efficiency in Rice

Advanced Science, EarlyView.
Based on large‐scale screening of 420 rice accessions, GWAS identified the Rc locus as a key regulator of EMS mutagenesis efficiency. Functional Rc alleles enhance both seed survival and genome‐wide mutation frequency by boosting antioxidant enzyme activities (CAT, SOD, POD) and reducing oxidative damage.
Peizhou Xu, Qinglu Zhang, Le Xue, Zhen Zhang, Nanhui Luo, Zhaoyang Cheng, Duo Xia, Shuqin Zheng, Xianjun Wu, Hao Zhou   +9 more
wiley   +1 more source

Physiological stage-dependent effects of <i>Mycobacterium tuberculosis</i> on human placental tissue: insights into early reactivation and immune modulation. [PDF]

Front Microbiol
Fonseca-Perez MS, Villavicencio-Carrisoza O, Grobeisen-Duque O, Herrera-Moro-Huitron LA, Flores-Pliego A, Espejel-Nuñez A, Olmos-Ortiz A, Del-Castillo-Hernandez BB, Rojo-Garcia JR, Rivera-Gutierrez S, Cerna-Cortes JF, Zaga-Clavellina V, Villegas-Mota MI, Aguilar-Ayala DA, Valdespino-Vazquez MY, Helguera-Repetto AC.   +15 more
europepmc   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Optimizing gibberellic acid concentration and exposure time for effective dormancy breaking and sprouting enhancement in potato. [PDF]

Sci Rep
Qayyum MM, Shahzad U, Jahan MS, El-Beltagi HS, Ghuffar S, Qasim M, Mehmood N, Anwaar S, Qureshi H, Anwar T, Rebouh NY, Shah MA, Muminov MM.   +12 more
europepmc   +1 more source

Mechanical Stimuli‐Induced Manipulation of Malignant Behavior in Bioprinted Cancer Microtissues via PI3K/NF‐κB Activation

Advanced Science, EarlyView.
A mechanically tunable ECM platform is created by integrating dECM–alginate matrices with in‐bath tumor printing. The mechanically tunable ECM environment drives tumors to acquire hypoxia, mechanotransduction signaling, metastatic traits, and drug‐resistant phenotypes that collectively promote malignant transformation.
Seok‐Hyeon Lee, Jeongho Lee, Min‐Seo Choi, Minjun Ahn, Sik Yoon, Dongjun Lee, Sae‐Ock Oh, Won‐Woo Cho, Byoung Soo Kim   +8 more
wiley   +1 more source

Temperature Perception Regulates Seed Germination in <i>Solanum nigrum</i> via Phytohormone Signaling Pathways. [PDF]

Int J Mol Sci
Ma Z, Yang L, Feng Z, Li L, Wu K, Xiong Y, Huang H, Wei S.   +7 more
europepmc   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Seed fatty acid composition and physical dormancy in fire-prone ecosystems. [PDF]

Ann Bot
McInnes SJ, Tangney R, Ooi MKJ.
europepmc   +1 more source