Results 181 to 190 of about 12,152 (228)

Expanded characterization of the valproic acid zebrafish larval model of autism spectrum disorder: Insights into dysregulation in the gut

Animal Models and Experimental Medicine, EarlyView.
Meticulous calculation of zebrafish‐equivalent therapeutic valproic acid (VPA) dosage maximized the translational value of the data. Hyposerotonergic tone underpinned an anxiety‐like outcome as a core symptom of autism spectrum disorder (ASD). Compartment‐specific dopaminergic and serotonergic dysregulation in the brain versus gut provided mechanistic ...
Lesha Pretorius, Johanna Adriana Coetzee, Alexio Pedro dos Santos, Carine Smith   +3 more
wiley   +1 more source

Microplastic Contamination in Amphibians and Reptiles: An Ecotoxicological Synthesis of Exposure, Mechanisms, and Risk Implications. [PDF]

Toxics
Berber AA, Akbulut C, Demir ŞN, Kurnaz M.   +3 more
europepmc   +1 more source

A novel thermal comfort model for older adults - development and validation of the COMFA-OA model. [PDF]

Build Environ
Li X, Zhang Y, Sang H, Lee C, Sullivan WC, Maddock JE, Li D, Brown RD.   +7 more
europepmc   +1 more source

A Ruthenium(CAAC‐5) Olefin Metathesis Catalyst for Bioconjugation

Angewandte Chemie International Edition, EarlyView.
The aqueous instability of ruthenium catalysts restricts olefin metathesis in biological media. A Ru(CAAC‐5) complex bearing an aniline handle is reported that remains active under biologically relevant conditions and enables bioconjugation to proteins, peptides, and an artificial metalloenzyme, providing a robust platform for olefin metathesis in ...
Damian Alexander Graf, Mikhail Boym, María Álvarez, Tsvetan Kardashliev, Thomas R. Ward   +4 more
wiley   +1 more source

From street level to science: advancing methods for climate walks to improve human thermal comfort. [PDF]

Int J Biometeorol
Lau K, Lam CKC, Krüger E, Nouri AS, Peng Z, Santucci D, Matzarakis A.   +6 more
europepmc   +1 more source

Click‐to‐Release Reactivity of Quaternary Anilinium Tetrazines Enables Cascade Assembly of Multifunctional Biomolecular Scaffolds

Angewandte Chemie International Edition, EarlyView.
Click chemistry has evolved from making covalent connections to also breaking bonds. Here, a cascade assembly is reported that combines these maneuvers to build multifunctional biomolecular scaffolds in a modular one‐pot reaction. The unifying azide release‐tetrazine hub clicks with a trans‐cyclooctene tag, rapidly liberates N,N‐dimethylaniline to ...
Markus Staudt, Christian B. M. Poulie, Andreas Löffler, Peter R. Meinig, Riley J. Deutsch‐Williams, Barbara Herrmann, Ralph Weissleder, Hannes Mikula, Jonathan C. T. Carlson, Matthias M. Herth   +9 more
wiley   +1 more source

Structure-based redesign enables clinical translation of CAIX-targeted theranostics in clear cell renal cell carcinoma. [PDF]

Theranostics
Xu Z, Zhou H, Dong Y, Feng D, Chen B, Li H, Yang R, Li N, Cao Y, He H, Wu H, Zhong Y, Wu H, Zhao L, Chen H, Hu K.   +15 more
europepmc   +1 more source

Integrated Electromicrobial Production of Itaconic Acid From CO2 at Liter‐Scale Using Komagataella phaffii

Angewandte Chemie International Edition, EarlyView.
This study demonstrates a novel hybrid system that integrates electrochemical CO2 reduction with microbial biosynthesis in a single reactor, using a synthetic autotrophic yeast to produce itaconic acid from CO2. Using an industrial yeast provides feasibility of direct electromicrobial CO2 conversion to bio‐based building blocks while identifying key ...
Paniz Izadi, Manja M. Severinsen Zijlstra, Aykut Kas, Philip Haus, Verena Enzinger, Gregor Lutz, Özge Ata, Simone Bachleitner, Diethard Mattanovich, Falk Harnisch   +9 more
wiley   +1 more source

Discovery of the Cyclic Form of MRI pH‐Sensor Z‐OMPD Enables >5% 13C Hyperpolarization by SABRE

Angewandte Chemie International Edition, EarlyView.
With “c‐OMPD”, we discovered a previously unknown 5‐membered lactol structure that arises from the homoaldol condensation of the central metabolite pyruvic acid. We demonstrate that the cyclization equilibrium is of crucial importance for OMPD's function as MRI‐based pH sensor and achieve for the first time 13C polarization levels (>5%) by SABRE in the
Juanita Ferreira, Ivan A. Trofimov, Martin Grashei, Adriana Sacristán‐Martín, Alexander Huber, David Schleicher, Oleksiy Khavryuchenko, Franz Schilling, Andreas B. Schmidt, Max von Delius   +9 more
wiley   +1 more source

Structure-Guided Extremophile Genome Mining Expands the PETase Landscape and Reveals PET-Hydrolysing True Lipase Lineages. [PDF]

Microb Biotechnol
Muñoz-Tafalla R, González-Romero JM, Vidal P, Fernandez-Lopez L, Robles-Martín A, Almendral D, Gonzalez-Alfonso JL, Plou FJ, Ferrer M, Guallar V, Bargiela R.   +10 more
europepmc   +1 more source