Results 211 to 220 of about 50,016 (309)

Digital performance testing reveals how redesigned return cannulas can enhance VV-ECMO performance. [PDF]

Intensive Care Med Exp
Ondrusova B, Petras A, Szasz J, Meier J, Gerardo-Giorda L.   +4 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Cilia-driven surface currents characterize specific cnidarian groups and lifecycle stages. [PDF]

Commun Biol
Koch T, Araslanova K, Bouderlique T, Fetisov A, Link O, Klimovich A, Mičić M, Mičić K, Boström J, Frade P, Abed-Navandi D, Adameyko I.   +11 more
europepmc   +1 more source

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis Care &Research, EarlyView.
Objective The objective is to describe and compare demographic, clinical, and serological characteristics of patients with systemic sclerosis (SSc) according to ethnic background. Methods Participants enrolled in the Canadian Scleroderma Research Group cohort who self‐identified to a single ethnicity group were included.
Danick Goulet, Camille Guertin, Maggie Larché, Isabelle Ferdinand, Marie Hudson, May Y. Choi, Mohammed Osman, Janet Pope, Carter Thorne, Murray Baron, Sasha Bernatsky, Sabrina Hoa   +11 more
wiley   +1 more source

Variability in the circulation of cerebrospinal fluid: causes and clinical implications for intraventricular drug delivery. [PDF]

Front Drug Deliv
Engelhard HH, Balédent O, Borzage MT, Andrews-Jones L, Feldsien TM, Lefebvre DR.   +5 more
europepmc   +1 more source

Employment Trajectories of Patients with Systemic lupus erythematosus (SLE) and Factors Driving Transitions Between States

Arthritis Care &Research, Accepted Article.
Objective Systemic lupus erythematosus (SLE) significantly impacts employment capacity. This study aimed to investigate the impact of burden of disease activity, damage, and treatment on employment outcomes and transitions in patients with SLE. Materials and Methods Using data from a single center, we analyzed employment transitions, adjusted mean ...
Javier Mencia‐Ledo, Zahi Touma, Laura Whittall Garcia, Dafna Gladman, Behdin Nowrouzi‐Kia   +4 more
wiley   +1 more source

Hemodialysis Access-Related High-Output Heart Failure: From Mechanisms to Multidisciplinary Management. [PDF]

JACC Case Rep
Kamanu C, Oliveros E, Brailovsky Y.
europepmc   +1 more source

Adaptive Observer for Coupled Wave PDE and Infinite ODE With Sampled Data and Unknown Input: Application to Brain Hemodynamics Estimation

International Journal of Adaptive Control and Signal Processing, EarlyView.
This article proposes a convergent adaptive observer for a damped wave PDE and an infinite‐dimensional ODE coupled in cascade using sampled‐in‐space ODE state measurements. The proposed observer estimates the distributed states of the PDE and ODE along with unknown PDE parameters and spatial input.
Zehor Belkhatir, Sarah Mechhoud, Taous‐Meriem Laleg‐Kirati   +2 more
wiley   +1 more source

Coexistence of trapped and flow-transported nuclei enables fast pigeon post communication across multinucleated cell. [PDF]

Proc Natl Acad Sci U S A
Tong J, Wachinger K, Henn FK, Schramma N, Chen S, Alim K.   +5 more
europepmc   +1 more source