Results 111 to 120 of about 3,654,033 (309)

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Six transition patterns and seven capture types in different left bundle branch bipolar pacing configurations

Frontiers in Cardiovascular Medicine
AimsThis study aims to explore the different transition patterns and capture types during two bipolar pacing tests based on the selective left bundle branch (LBB) capture determined by the continuous pacing and recording technique.MethodsIn total, 67 ...
Lu Zhang, Longfu Jiang, Longfu Jiang, Binbin Luo, Jiabo Shen, Hao Wu, Weifang Zeng   +6 more
doaj   +1 more source

Perceived Time Shapes Physical Fatigue Accumulation and Its Neural Oscillatory Correlates

Advanced Science, EarlyView.
Can a clock change the course of physical fatigue? By covertly manipulating the clock calibration during repeated isometric contractions, we showed that perceived time shapes fatigue accumulation and frontal oscillatory dynamics. While fatigue accumulation was only reduced when the clock was slowed down, frontal oscillatory dynamics followed perceived ...
Pierre‐Marie Matta, Julien Duclay, Robin Baurès, Andrea Alamia   +3 more
wiley   +1 more source

Permanent Parahisian Pacing

Indian Pacing and Electrophysiology Journal, 2007
Right Ventricular Apical permanent pacing could have negative hemodynamic effects. A physiologic pacing modality should preserve a correct atrio-ventricular and interventricular synchronization.
Paolo Marino, Miriam Bortnik, Eraldo Occhetta   +2 more
doaj  

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Permanent His bundle pacing: Electrophysiological and echocardiographic observations from long-term follow-up

, 2017
Background Permanent His bundle pacing (HBP) is a physiological alternative to right ventricular pacing. It is not known whether HBP can cause His-Purkinje conduction (HPC) disease.
Lustgarten, Daniel, Dandamudi, Gopi, Pugazhendhi Vijayaraman, Kenneth A Ellenbogen, Daniel Lustgarten, Vijayaraman, Pugazhendhi, Gopi Dandamudi, Ellenbogen, Kenneth A.   +7 more
core   +1 more source

His Bundle Pacing in the Era of Left Bundle Branch Pacing

Arrhythmia & Electrophysiology Review
Soon after the rapid growth of the popularity of His bundle pacing (HBP), the use of this conduction system pacing modality was overshadowed by left bundle branch area pacing (LBBAP).
M. Jastrzębski, Weijian Huang, P. M. Vázquez, P. Vijayaraman   +3 more
semanticscholar   +1 more source

Atmospheric Water Harvesting Through Polymer Hydrogel Sorbents: Materials Chemistry, Design Strategies, and Applications

Advanced Science, EarlyView.
Polymer‐based hydrogels have emerged as promising materials for atmospheric water harvesting (AWH) due to their high water affinity, tunable network structure, and excellent moisture adsorption‐desorption performance. Functional hydrogel systems enable efficient water capture and controlled release under low‐energy conditions, offering a sustainable ...
Swagata Datta, Sushmit Sen, Nilanjan Dey, Amrita Chatterjee, Ananya Sadhu, Sudipta Sarkar, Pradip K. Maji   +6 more
wiley   +1 more source

Physiological pacing in young patients with complex congenital heart defects

, 2018
Aim: Young patients with operated complex congenital heart defects (CHD) often develop sinus node dysfunction (SND) requiring permanent pacing with rate-responsive function.
Fabrizio Drago, Camilla Calvieri, Massimo Stefano Silvetti, Sergio Torcinaro, Calvieri, Camilla, Irma Battipaglia, Saputo, Fabio Anselmo, Fabio Anselmo Saputo, Adriano Carotti, Corrado Di Mambro, Silvetti, Massimo Stefano, Di Mambro, Corrado, Pazzano, Vincenzo, Drago, Fabrizio, Verticelli, Letizia, Carotti, Adriano, Vincenzo Pazzano, Torcinaro, Sergio, Battipaglia, Irma, Letizia Verticelli   +19 more
core   +1 more source

Conduction system pacing: What is new in 2025 Clinical Consensus Statement

Heart Vessels and Transplantation
Conduction system pacing (CSP), which includes His bundle pacing (HBP) and left bundle branch area pacing (LBBAP), is increasingly recognized as a physiological and clinically effective alternative to conventional right ventricular pacing (RVP) and ...
Oleh Semeniuk, Mykhaylo Sorokivskyy, Ulyana Chernyaha-Royko , Oleh Zharinov   +3 more
doaj   +1 more source