Results 51 to 60 of about 3,318,539 (291)

How does homeostasis happen? Integrative physiological, systems biological, and evolutionary perspectives.

American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2019
Homeostasis is a founding principle of integrative physiology. In current systems biology, however, homeostasis seems almost invisible. Is homeostasis a key goal driving body processes, or is it an emergent mechanistic fact?
D. Goldstein
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of a multi-professional program on promoting the food health of the elderly: a longitudinal study.

Revista Española de Nutrición Humana y Dietética, 2021
Objective: To analyze the food quality of elderly participants in a multi-professional project for health promotion and healthy longevity. Methodology: 55 older adults aged ≥ 60 years (66.03 ± 3.68 years) residents in the south of Brazil were recruited.
Déborah Cristina de Souza Marques, Isabella Caroline dos Santos, Nathália Lira Campinha, Marilene Ghiraldi de Souza Marques, Fabiano Mendes de Oliveira, Braulio Henrique Magnani Branco   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Ultra-processed foods consumption among children and associated socioeconomic and demographic factors

Einstein (São Paulo), 2021
Objective To evaluate the consumption of ultra-processed foods among children, and to investigate associations with socioeconomic and demographic factors.
Eveline Costa Cainelli, Brunna Verna Castro Gondinho, Danielle da Costa Palacio, Daniele Boina de Oliveira, Roberta Andrade Reis, Karine Laura Cortellazzi, Luciane Miranda Guerra, Denise de Fátima Barros Cavalcante, Antonio Carlos Pereira, Jaqueline Vilela Bulgareli   +9 more
doaj   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Novel insight into pressurization of the male and female urethra through application of a multi-channel fibre-optic pressure transducer: Proof of concept and validation

Investigative and Clinical Urology, 2020
Purpose: To confirm feasibility of recording pressure along the length of the urethra using a multi-sensor fibre-optic pressure catheter; to identify the spatial and temporal features of changes in pressure along the urethra at sites related to specific ...
Ryan E. Stafford , John Arkwright , Phil G. Dinning , Wolbert van den Hoorn , Paul W. Hodges   +4 more
doaj   +1 more source

FUNCTIONAL PERFORMANCE IN THE MODIFIED SHUTTLE TEST IN CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS

Revista Paulista de Pediatria, 2020
Objective: To evaluate factors associated with the performance of children and adolescents with cystic fibrosis (CF) in the Modified Shuttle Test (MST) and compare it with healthy children and adolescents.
Luanna Rodrigues Leite, Karen Caroline Vasconcelos Queiroz, Cristiane Cenachi Coelho, Alberto Andrade Vergara, Márcio Vinícius Fagundes Donadio, Evanirso da Silva Aquino   +5 more
doaj   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source