Results 61 to 70 of about 7,343 (217)

Examining AI-Powered ADHD Diagnosis: Current Trends, Key Challenges, and Future Directions in the Field

IEEE Access
Attention deficit hyperactivity disorder (ADHD) is a type of neurodevelopmental disease affecting the mental health of children and adults. Individuals with ADHD show various symptoms such as inattention, hyperactivity, and impulsivity.
Qurat Ul Ain, Soyiba Jawed, Ahmad Rauf Subhani, Wasi Haider Butt, Muhammad Usman Akram   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Optimizing Driver Vigilance Recognition: Examining the Characterization and Cumulative Effect of Physiological Signals Across Manual and Automated Driving and Durations

Applied Sciences
Identifying changes in driver’s vigilance under combined manual and automated driving conditions, as well as during prolonged driving, is crucial for reducing car crashes.
Mingyang Guo, Yuning Wei, Jingyuan Zhang, Qingyang Huang, Xiaoping Jin, Jun Ma   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Bayesian Residual Transform for Signal Processing

IEEE Access, 2015
Multiscale decomposition has been an invaluable tool for the processing of physiological signals. Much focus on multiscale decomposition for processing such signals have been based on scale-space theory and wavelet transforms.
Alexander Wong, Xiao Yu Wang
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Studying the Spatial Distribution of Physiological Effects on BOLD Signals using Ultrafast fMRI

Frontiers in Human Neuroscience, 2014
The blood-oxygen-level dependent (BOLD) signal in fMRI reflects both neuronal activations and global physiological fluctuations. These physiological fluctuations can be attributed to physiological low frequency oscillations (pLFOs), respiration, and ...
Yunjie eTong, Yunjie eTong, Blaise deB Frederick, Blaise deB Frederick   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source