Results 191 to 200 of about 2,132,125 (311)

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Arbuscular mycorrhizal fungi and mycorrhizal helper bacteria co-inoculation alters drought-associated physiological traits and leaf abscisic acid concentration in citrus rootstocks. [PDF]

PLoS One
Barman P, Singh SK, Kumar R, Mishra DS, Shukla A, Pandey AK, Khadivi A, Tunç Y.   +7 more
europepmc   +1 more source

Determination of Gene‐Level Fitness Contributions Across the Mucin‐Utilization Network of Bacteroides thetaiotaomicron

Advanced Science, EarlyView.
Genome‐wide CRISPRi and RNA‐seq resolve how B. thetaiotaomicron converts host mucosal glycans into fitness. The study reveals a layered mucin‐utilization architecture in which capsular polysaccharides constrain surface access, extracellular CAZymes and peptidases show functional redundancy, and intracellular catabolic pathways create discrete metabolic
Kangsan Kim, Jiwon Lee, Minjeong Kang, Sung Sun Yim, Donghui Choe, Byung‐Kwan Cho   +5 more
wiley   +1 more source

Microbial Inoculation Enhances Growth and Physiological Traits of Tissue Cultured <i>Panicum turgidum</i> Forssk. Plantlets During Acclimatization. [PDF]

Plants (Basel)
Habib MM, Dewir YH, Alshahrani TS, Malik JA, Dar BA, Al-Qarawi AA.   +5 more
europepmc   +1 more source

An Integrated Artificial Intelligence Framework for Nanomedicine Engineering

Advanced Science, EarlyView.
This review outlines a closed‐loop AI ecosystem for nanomedicine engineering. By synergizing multimodal data harmonization, objective‐driven AI architectures, and automated high‐throughput validation, this “Design‐Make‐Test‐Analyze” (DMTA) workflow transforms traditional heuristic formulation into a predictive, self‐optimizing paradigm, accelerating ...
Meichen Dong, Qin Luo, Xinyi Ding, Chaoqi Lu, Ru Zhang, Qingqing Tan, Zhiqing Pang, Defang Ouyang, Dongsheng Li, Jiaxuan Xia, Jianxin Wang   +10 more
wiley   +1 more source

Comparative analysis of salt tolerance and associated physiological traits in wild and cultivated barley at the seedling stage. [PDF]

BMC Plant Biol
Zhang Y, Yin X, Cao C, Zhang M, Li L, Zhu J, Hong Y, Lv C, Guo B, Wang F, Luobu Z, Xu R.   +11 more
europepmc   +1 more source

ELF5‐Mediated Enhancer–Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland

Advanced Science, EarlyView.
In the study, we systematically investigate the epigenetic mechanisms underlying lactation traits in sheep by integrating transcriptomic, chromatin accessibility, histone modification, and functional analyses. We identify a super‐enhancer at the LALBA locus and demonstrate that enhancer E4 functions as its core regulatory element.
Xinmiao Wu, Jiqing Wang, Zhiyun Hao, Mingna Li, Huimin Zhen, Yuan Liu, Guoyong Zhao, Chunyan Ren, Xuelan Zhou, Haixiong Hu, Mingjie Li, Nan Shi   +11 more
wiley   +1 more source

Interactive effects of ETc-based drip irrigation scheduling and phytohormones on root architecture, physiological traits and yield of wheat. [PDF]

Sci Rep
Banik B, Korav S, Sujatha HT, Sharma V, Al-Dosary MA, Al Otaibi WS, Alamri S, Siddiqui MH, Jha PK, Hussan MU.   +9 more
europepmc   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Carbon Nanoparticles Enhance Drought Tolerance Through the Improvement of Morphological and Physiological Traits in Maize Hybrids. [PDF]

Plants (Basel)
Vilas Boas JK, Steiner F, Soares GR, Aguilera JG, Zuffo AM, Peñuelas-Rubio O, Argentel-Martínez L, Azizoglu U.   +7 more
europepmc   +1 more source