Results 71 to 80 of about 2,810,314 (307)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
InformationRemote assistance for highly automated vehicles (HAVs), i.e., third-party assistance from support staff outside the vehicle in times of the need for assistance, presents a solution to extend the capabilities of HAVs by integrating a third party for ...
Fabian Walocha +3 more
doaj +1 more source
Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior. [PDF]
, 2017 Functional imaging and gene expression studies both implicate the medial prefrontal cortex (mPFC), particularly deep-layer projection neurons, as a potential locus for autism pathology.
Brumback, AC +9 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
To germinate or not to germinate : a question of dormancy relief not germination stimulation [PDF]
, 2012 A common understanding of the control of germination through dormancy is essential for effective communication between seed scientists whether they are ecologists, physiologists or molecular biologists. Vleeshouwers et al.
Batlla +4 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Revista Brasileira de Engenharia Agrícola e AmbientalVariations in environmental conditions, such as the availability of light, can affect the efficacy of herbicides because they alter the biological characteristics of plants including those that are related to the plant’s sensitivity to herbicides ...
Gustavo A. Costa +5 more
doaj +1 more source
Publications of the Space Physiology and Countermeasures Program, Cardiopulmonary Discipline: 1980-1990 [PDF]
A 10-year cumulative bibliography of publications resulting from research supported by the Cardiopulmonary Discipline of the Space Physiology and Countermeasures Program of NASA's Life Sciences Division is provided.
Dickson, Katherine J. +3 more
core +1 more source
Partial differential equations in medical biophysics [PDF]
, 1982 A number of examples of collaborative research are outlined which show how mathematicians and medical biophysicists have contributed to a wider understanding of some problems in applied ...
Twizell, E H
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source