Results 71 to 80 of about 1,308,964 (265)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
InformationRemote assistance for highly automated vehicles (HAVs), i.e., third-party assistance from support staff outside the vehicle in times of the need for assistance, presents a solution to extend the capabilities of HAVs by integrating a third party for ...
Fabian Walocha +3 more
doaj +1 more source
Physiology in Perspective: The Value of Integrative Physiology [PDF]
Physiology, 2017 Almost a year ago, I gained a close and personal appreciation for the value gained from an understanding of integrative physiology. Suddenly one morning, while on vacation, I was struck by a massive pulmonary embolism and experienced first hand the importance of the interaction between the ...
openaire +2 more sources
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Revista Brasileira de Engenharia Agrícola e AmbientalVariations in environmental conditions, such as the availability of light, can affect the efficacy of herbicides because they alter the biological characteristics of plants including those that are related to the plant’s sensitivity to herbicides ...
Gustavo A. Costa +5 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Editorial: The art of teaching physiology: its place in the integrated curriculum
Frontiers in Physiology, 2023 Amberly Reynolds, Irina Nizamutdinova
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source