Results 141 to 150 of about 56,586 (257)

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

Phytotherapy Research, EarlyView.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli, Giovanni Roviello, Giorgia Magliocca, Emilia Esposito, Anna Pannaccione   +4 more
wiley   +1 more source

Epigallocatechin‐3‐Gallate Suppresses Glioma by Targeting Integrin αvβ3/FAK/ERK Signaling Axis and Matrix Metalloproteinases

Phytotherapy Research, EarlyView.
EGCG suppresses glioma progression by targeting integrin αvβ3/FAK/ERK signaling and inhibiting MMP‐2/MMP‐9‐mediated ECM degradation, thereby blocking proliferation, migration, invasion, and promoting apoptosis. ABSTRACT Epigallocatechin‐3‐gallate (EGCG), the most abundant and biologically active catechin in green tea, has been widely reported to ...
Rui Sun, Yonghan Pan, Ning Yang, Bing Kang, Hong Xiao, Xianglong Tang, Taiping Li, Mengjie Zhao   +7 more
wiley   +1 more source

Efficacy of Plant‐Derived Therapies for Primary Dysmenorrhea: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Phytotherapy Research, EarlyView.
ABSTRACT Primary dysmenorrhea is defined as recurrent, cramp‐like lower abdominal pain occurring during menstruation in the absence of underlying pelvic pathology. A significant proportion of the population opts for natural plant‐based remedies due to their perceived lower incidence of adverse effects.
Lifei Wu, Inmaculada Xu Lou, Zhenting Hu, Gan Wang, Sammit Vishram Deshpande, Rocío Cáceres‐Matos   +5 more
wiley   +1 more source

Curcumin Alleviates the Osteogenesis Inhibition and the Aging Process in BMSCs Induced by Iron Overload Through Activating the NRF2/GPX4 Pathway

Phytotherapy Research, EarlyView.
Under iron overload conditions, curcumin inhibits cellular senescence and promotes osteogenic differentiation by activating the NRF2/GPX4 signaling pathway in bone marrow mesenchymal stem cells (BMSCs), thereby preventing the onset of osteoporosis. ABSTRACT Dysregulated proliferation and differentiation of bone marrow mesenchymal stem cells (BMSCs ...
Jingmin Che, Qing Feng, Zhixia Zhao, Jingying Sun, Weihao Ren, Yangmeng Feng, Cuixiang Xu, Xu‐Hui Li   +7 more
wiley   +1 more source

Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms

Phytotherapy Research, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley   +1 more source

Cabomba caroliniana and Schoenoplectus californicus as Antifouling Candidates: Anti‐Attachment and Toxicological Effects in Aurelia coerulea (Cnidaria, Scyphozoa)

Environmental Toxicology, EarlyView.
ABSTRACT Biofouling on artificial surfaces in aquatic ecosystems leads to significant economic losses. Current antifouling paints, while effective, often harm the aquatic environment. This study explores ecologically safe antifouling alternatives derived from plants, focusing on the aquatic macrophytes Cabomba caroliniana (CC) and Schoenoplectus ...
Mikael Luiz Pereira Morales, Laís Olivera das Neves, Ayman Shaik, Hafizah Chenia, Maximiliano Manuel Maronna, Sanye Soroldoni, Renato Mitsuo Nagata, Ng Haig They, Vanessa Ochi Agostini, Grasiela Lopes Leães Pinho   +9 more
wiley   +1 more source

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

GRAYU: graph-based database integrating Ayurvedic formulations, medicinal plants, phytochemicals and diseases. [PDF]

Front Pharmacol
Joshi S, Pathak A, Regati DR, Menon R, Ajith DS, Sheshadri A, Viswanathan N, Ray P, Koul V, Panda P, Bhambore SA, Verma S, Sinha A, Shafi KM, Pavalam M, Sowdhamini R.   +15 more
europepmc   +1 more source

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

Artificial intelligence-based screening of phytochemicals for targeted cancer therapy. [PDF]

Nat Prod Bioprospect
Santiago LR, Asevedo EA, de Oliveira MEJ, Pereira KC, da Silva Trindade MF, Oliveira AGS, Rocha MA, Kang S, Rani A, Park MN, Tan MW, Tan MW, Syahputra RA, Kim B, de Azambuja Ribeiro RIM.   +14 more
europepmc   +1 more source