Results 201 to 210 of about 728,464 (246)

Limited Incremental Diagnostic Value of Perilesional and Systematic Biopsies in PI-RADS 4-5 Lesions: A Retrospective Single-Center Study. [PDF]

Cancers (Basel)
Scarrone E, Canale V, Antonelli L, Stira J, Gravina C, Zarrelli G, Sciarra A.   +6 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Impact of miR-146a-3p rs2910164 polymorphism on peri-implantitis susceptibility and target gene-mediated inflammatory responses. [PDF]

Acta Odontol Scand
Zhang Y, Wang S, Xie Z, Jiang Y, Li T.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Robust, Thermo-Malleable, and Closed-Loop Recyclable Mulberry Paper/Polyimine Composite Films Enabled by Dynamic Covalent Interpenetrating Networks. [PDF]

Materials (Basel)
Liao Y, Huang Y, Cheng P, Huang H, Liang L, Fan L, Lai H, Qi G, Min D, Li X, Wang C, Liu F.   +11 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Polyprenyl immunostimulant treatment during experimental feline herpesvirus-1 infection is associated with reduced ocular disease after conjunctival rechallenge. [PDF]

Front Vet Sci
Heidel RE, Kuritz T, Maes RK, Thompson D, Beasley M, Reinemeyer CR.   +5 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Skin thickness alterations in pressure injury tissue: insights from high-frequency ultrasound and mixed-design analysis of variance. [PDF]

Front Physiol
Tang L, Zhang J, Zhou W, Huang J, Diao D, Zhong L, Zhang J.   +6 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source